ArticleFrontiers in public health2023
Occupational factors and low back pain: a Mendelian randomization study.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Predicting low back pain-related absenteeism in the Spanish general working population.Occupational and environmental medicine · 2026Observational
- The Effectiveness of Traditional Chinese Medicine Integrated with Self-Slump Stretching on Chronic Low Back Pain among Hill Tribe Farmers in Thailand: a pilot randomized controlled trial.Journal of pharmacopuncture · 2025Article
- Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Chronic low back pain causal risk factors identified by Mendelian randomization: a cross-sectional cohort analysis.The spine journal : official journal of the North American Spine Society · 2025Observational
- Low back pain among the working-age population: from the global burden of disease study 2021.BMC musculoskeletal disorders · 2025Article
- Global burden of occupational ergonomic factor-induced low back pain, 1990~2021: data analysis and projections of the global burden of disease.Frontiers in public health · 2025Article
- Modifiable risk factors that mediate the effect of insomnia on the risk of low back pain: a network mendelian randomization study.Hereditas · 2024Article
- Chronic Low Back Pain Causal Risk Factors Identified by Mendelian Randomization: a Cross-Sectional Cohort Analysis.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Low back pain (LBP) is a common condition and a leading cause of health function loss worldwide. This study assessed the impact of occupational factors on LBP using Mendelian Randomization (MR) method, controlling for confounding variables. Methods: Based on publicly available genome-wide association studies (GWAS), two-sample univariate and multivariate MR analyses were performed to assess the causal effect of occupational factors on LBP. We used the inverse variance weighted (IVW) method and sensitivity analyses to generate the total results for the univariate MR analysis. Furthermore, we performed multivariate MR analysis to assess the direct causal association between occupational factors and LBP after accounting for potential confounding variables. Results: The total causal effect of genetically predicted job involves heavy manual or physical work on LBP was found to be significant (IVW OR, 2.117; 95% CI, 1,288-3.479; Conclusion: Our results supported a causal link between job involves heavy manual or physical work and increased risk of LBP, while finding no significant associations between prolonged walking/standing at work, job satisfaction, and LBP, providing valuable insights for the development of targeted prevention and intervention strategies for LBP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.