Evidence map›Paper›PMID 37710973›Full record

ArticleCell transplantation

Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite.

Masahide Takedachi, Kohsuke Kawasaki, Keigo Sawada, Kazuma Sakura, Mari Murata, Junpei Shimomura, Kazuma Kawakami, Chiaki Morimoto, Koji Miki, Noboru Takeshita and 6 more

Abstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Masahide TakedachiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.ORCID 0000-0003-0331-3478
Kohsuke KawasakiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Keigo SawadaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.ORCID 0000-0002-9187-2386
Kazuma SakuraDepartment of Medical Innovation, Osaka University Hospital, Suita, Japan.
Mari MurataDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Junpei ShimomuraDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Kazuma KawakamiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Chiaki MorimotoDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Koji MikiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Noboru TakeshitaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Tomoaki IwayamaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Hanayuki OkuraCenter for Reverse Translational Research, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Habikino, Japan.
Akifumi MatsuyamaCenter for Reverse Translational Research, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Habikino, Japan.
Masahiro SaitoDepartment of Restorative Dentistry, Division of Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Masahiro KitamuraDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.
Shinya MurakamiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed an autologous transplantation method using adipose tissue-derived multi-lineage progenitor cells (ADMPCs) as a method of periodontal tissue regeneration that can be adapted to severe periodontal disease. Our previous clinical study confirmed the safety of autologous transplantation of ADMPCs and demonstrated its usefulness in the treatment of severe periodontal disease. However, in the same clinical study, we found that the fibrin gel used as the scaffold material might have caused gingival recession and impaired tissue regeneration in some patients. Carbonate apatite has a high space-making capacity and has been approved in Japan for periodontal tissue regeneration. In this study, we selected carbonate apatite as a candidate scaffold material for ADMPCs and conducted an

Indexed as

Bone RegenerationPeriodontal DiseasesAdipose TissueAnimalsApatitesDogsGuided Tissue Regeneration, PeriodontalHumansStem CellsTransplantation, AutologousApatitescarboapatiteadipose tissueautologous transplantationcarbonate apatitemesenchymal stem cellperiodontal tissue regeneration

Identifiers

PMID37710973
PMCPMC10503283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.