ArticleJournal of the American Chemical Society2023
Timed Pulses in DNA Strand Displacement Reactions.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- ATP-fueled autonomous pathway-selective signal transduction on DNA-nanostructure tracks.Nature communications · 2026Article
- Enzymatic DNA Reaction Networks for Orchestrating Stimuli-Dependent Temporal Molecular Pulse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Enzyme-Free DNA Logic Circuit with Single-Color Readout for Dual Biomarker Detection.Applied biochemistry and biotechnology · 2026Article
- Conformation-programmed DNA computing.Science advances · 2026Article
- Spring-loaded DNA origami arrays as energy-supplied hardware for modular nanorobots.Science robotics · 2025Article
- Sustained, Reversible, and Adaptive Non-Equilibrium Steady States of a Dissipative DNA-Based System.Angewandte Chemie (International ed. in English) · 2025Article
- Kinetics and Activation Strategies in Toehold-Mediated and Toehold-Free DNA Strand Displacement.Biosensors · 2025Review
- Designing a DNA synchronizer for compact single-rail DNA logic circuits.Science advances · 2025Article
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
- Enzyme-Responsive DNA Condensates.Journal of the American Chemical Society · 2024Article
- Temporally controlled multistep division of DNA droplets for dynamic artificial cells.Nature communications · 2024Article
- A DNA rotary nanodevice operated by enzyme-initiated strand resetting.Chemical communications (Cambridge, England) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by naturally occurring regulatory mechanisms that allow complex temporal pulse features with programmable delays, we demonstrate here a strategy to achieve temporally programmed pulse output signals in DNA-based strand displacement reactions (SDRs). To achieve this, we rationally designed input strands that, once bound to their target duplex, can be gradually degraded, resulting in a pulse output signal. We also designed blocker strands that suppress strand displacement and determine the time at which the pulse reaction is generated. We show that by controlling the degradation rate of blocker and input strands, we can finely control the delayed pulse output over a range of 10 h. We also prove that it is possible to orthogonally delay two different pulse reactions in the same solution by taking advantage of the specificity of the degradation reactions for the input and blocker strands. Finally, we show here two possible applications of such delayed pulse SDRs: the time-programmed pulse decoration of DNA nanostructures and the sequentially appearing and self-erasing formation of DNA-based patterns.
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