Evidence map›Paper›PMID 37710421›Full record

SynthesisClinical and experimental dental research2023

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis.

Athanasios Fasoulas, Georgios Keratiotis, Loukia Spineli, Nikos Pandis, Mieke A A De Bruyne, Roeland J G De Moor, Maarten A Meire

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and experimental dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Athanasios FasoulasDepartment of Oral Health Sciences, Section of Endodontology, Ghent University, Ghent, Belgium.ORCID 0000-0001-9272-7677
Georgios KeratiotisDepartment of Oral Health Sciences, Section of Endodontology, Ghent University, Ghent, Belgium.
Loukia SpineliMidwifery Research and Education Unit, Hannover Medical School, Hannover, Germany.
Nikos PandisDepartment of Orthodontics and Dentofacial Orthopaedics, University of Bern, Bern, Switzerland.
Mieke A A De BruyneDepartment of Oral Health Sciences, Section of Endodontology, Ghent University, Ghent, Belgium.
Roeland J G De MoorDepartment of Oral Health Sciences, Section of Endodontology, Ghent University, Ghent, Belgium.
Maarten A MeireDepartment of Oral Health Sciences, Section of Endodontology, Ghent University, Ghent, Belgium.

Funding

University of Ghent
6 · The paper itself

Abstract

objectivesDifferent materials have been used for capping the pulp after exposure during caries removal in permanent teeth. The purpose of this study was to collate and analyze all pertinent evidence from randomized controlled trials (RCTs) on different materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth. MATERIALS AND

methodsTrials comparing two or more capping agents used for direct pulp capping (DPC) or pulpotomy were considered eligible. An electronic search of four databases and two clinical trial registries was carried out up to February 28, 2021 using a search strategy properly adapted to the PICO framework. Screening, data extraction, and risk of bias (RoB) assessment of primary studies were performed in duplicate and independently. The primary outcome was clinical and radiological success; secondary outcomes included continued root formation, tooth discoloration, and dentin bridge formation.

results21 RCTs were included in the study. The RoB assessment indicated a moderate risk among the studies. Due to significant clinical and statistical heterogeneity among the studies, performing network meta-analysis (NMA) was not possible. An ad hoc subgroup analysis revealed strong evidence of a higher success of DPC with Mineral Trioxide Aggregate (MTA) compared to calcium hydroxide (CH) (odds ratio [OR] = 3.10, 95% confidence interval [CI]: 1.66-5.79). MTA performed better than CH in pulp capping (both DPC and pulpotomy) of mature compared to immature teeth (OR = 3.34, 95% CI: 1.81-6.17). The GRADE assessment revealed moderate strength of evidence for DPC and mature teeth, and low to very low strength of evidence for the remaining subgroups.

conclusionsConsiderable clinical and statistical heterogeneity among the trials did not allow NMA. The ad hoc subgroup analysis indicated that the clinical and radiographic success of MTA was higher than that of CH but only in mature teeth and DPC cases where the strength of evidence was moderate. PROSPERO Registration: number CRD42020127239.

Indexed as

Dental CariesDental Pulp CappingAluminum CompoundsCalcium CompoundsCalcium HydroxideDrug CombinationsHumansOxidesPulpotomyRandomized Controlled Trials as TopicSilicatesAluminum CompoundsCalcium CompoundsCalcium HydroxideDrug CombinationsOxidesSilicatesBiodentinecalcium hydroxidedirect pulp cappingMTApulpotomyvital pulp treatment

Identifiers

PMID37710421
PMCPMC10728530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.