Evidence map›Paper›PMID 37710328›Full record

ArticleBiomaterials research2023

Silver nanoparticles-decorated extracellular matrix graft: fabrication and tendon reconstruction performance.

Sunfang Chen, Dan Cai, Qi Dong, Gaoxiang Ma, Chennan Xu, Xiaogang Bao, Wei Yuan, Bing Wu, Bin Fang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Sunfang Chen *Department of Orthopedics, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310000, China.
Dan Cai *Department of Orthopedics, the First People's Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, 313000, China.
Qi Dong *Department of Orthopedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an City, 710054, China.
Gaoxiang MaDepartment of Orthopedics, the Central Hospital Affiliated to Shaoxing University, Shaoxing, 312030, China.
Chennan XuDepartment of Orthopedics, the Central Hospital Affiliated to Shaoxing University, Shaoxing, 312030, China.
Xiaogang BaoDepartment of Orthopedics, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Wei YuanDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China. wei95960@126.com.
Bing WuDepartment of Orthopedics, the Central Hospital Affiliated to Shaoxing University, Shaoxing, 312030, China. wubing@usx.edu.cn.
Bin FangDepartment of Orthopedics, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310000, China. 20233006@zcmu.edu.cn.
Shaoxing People's Hospital · CNHuzhou University · CNSecond Military Medical University · CNShanghai University of Traditional Chinese Medicine · CNShaoxing University · CNZhejiang Chinese Medical University · CN

Funding

Medical and Health Science and Technology Plan Project of Zhejiang Province grant No. 2022KY416Medical and Health Science and Technology Plan Project of Zhejiang Province grant No. 2023KY374Natural Science Foundation of Zhejiang Province grant No. LBY22H180007Natural Science Foundation of Zhejiang Province grant No. LBY22H270004Shanghai Municipal Health Commission grant No. 202040317Shanghai Sailing Program Grant No. 21YF1458200
6 · The paper itself

Abstract

backgroundThe reconstruction of tendons with large defects requires grafts with high mechanical strength and is often hindered by complications such as infection and adhesion. Hence, grafts combining the advantages of mechanical resilience and antibacterial/antiadhesion activity are highly sought after.

methodsThe silver nanoparticles (GA-Ag NPs) synthesized from gallic acid and silver nitrate were attached to a decellularized extracellular matrix (Decellularized Tendon crosslinking GA-AgNPs, DT-Ag). We examined the histological structure, mechanical property, morphology, Zeta potential, cytotoxicity, antibacterial properties, antioxidant and anti-inflammatory properties, and ability of the DT-Ag to treat tendon defects in animals.

resultsApproximately 108.57 ± 0.94 μg GA-Ag NPs loaded per 50 mg DT, the cross-linked part of GA-Ag NPs was 65.47 ± 0.57%, which provided DT-Ag with long-lasting antibacterial activity. Meanwhile, GA endowed DT-Ag with good antioxidant and anti-inflammatory activities. Additionally, The DT-Ag facilitated M2 macrophage polarization, and suppressed fibrin deposition by hindering fibroblast adhesion. Mormore, the main advantages of DT-Ag, namely its long-lasting antibacterial activity (tested using Escherichia coli and Staphylococcus aureus as models) and the ability to prevent tissue adhesion were confirmed in vivo.

conclusionThe fabricated multifunctional tendon graft was highly hydrophilic, biocompatible, and mechanically resilient, and concluded to be well suited for dealing with the main complications of surgical tendon reconstruction and has bright application prospects.

Indexed as

Extracellular matrixInfectionInflammationSilver nanoparticlesTendon graft

Identifiers

PMID37710328
PMCPMC10503197
OpenAlexW4386744553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.