SynthesisVirology journal2023
The effect of hepatitis B virus on the risk of pregnancy outcomes: a systematic review and meta-analysis of cohort studies.
Synthesis in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Non-genetic risk factors of miscarriage: a comprehensive umbrella review of systematic review and meta-analysis.Reproductive health · 2025Pooled it
- Prevalence of hepatitis B virus infection and its associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis of data published from 2003 to 2024.Archives of public health = Archives belges de sante publique · 2025Pooled it
- Global burden and forecast of acute viral hepatitis B among women of childbearing age: a systematic analysis of the global burden of disease study 2021.BMC infectious diseases · 2026Article
- Association between maternal HBV-DNA levels and pregnancy outcomes among hepatitis B carriers: a retrospective cohort study in China.BMC pregnancy and childbirth · 2026Article
- Concurrent uterine rupture and refractory uterine atony leading to catastrophic postpartum hemorrhage: a case report.International journal of surgery case reports · 2026Article
- Global, regional, and national burdens of liver disease due to hepatitis B in women of childbearing age, 1990 to 2021: an analysis of the Global Burden of Disease Study.AJOG global reports · 2026Article
- The impact of maternal hepatitis B virus infection on IVF/ICSI-assisted pregnancy outcomes: a propensity score-matched cohort study.Frontiers in medicine · 2026Article
- Retrospective analysis of adverse pregnancy outcomes associated with hepatitis B virus infection.BMC pregnancy and childbirth · 2025Article
- Article
- Hepatitis B virus infection and associated risk factors among mothers attending public health facilities in Bahir Dar, Northwest Ethiopia.Scientific reports · 2025Article
- Risk factors for neonatal mortality: an umbrella review of systematic reviews and meta-analyses.EClinicalMedicine · 2025Review
- The impact of gestational diabetes mellitus on pregnancy outcomes in women with hepatitis B virus: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Risk of adverse obstetrical and neonatal outcomes in women consuming recreational drugs during pregnancy.BMC pregnancy and childbirth · 2025Observational
- Article
- Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected?PLOS global public health · 2025Review
- Defining knowledge gaps in preterm birth research: Can biomarkers fill the gaps?Frontiers in medicine · 2025Review
- Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns.Antioxidants (Basel, Switzerland) · 2024Review
- Improving integrated perinatal care for women with hepatitis B in China.BMJ (Clinical research ed.) · 2024Article
- Navigating Perinatal Challenges: A Comprehensive Review of Hepatitis B Viral Infection and Pregnancy Outcomes.Cureus · 2024Review
- Maternal multimorbidity and chronic conditions as predictors of preterm birth: A matched case-control study in Cyprus.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of HBV on neonatal and maternal outcomes can create a basis for more accurate clinical decision-making. So, the aim of this meta-analysis is to detrmine the effect of chronic hepatitis B virus on the risk of pregnancy outcomes by combining cohort studies.
methodsInternational databases in this meta-analysis included the Cumulated Index to Nursing and Allied Health Literature (CINAHL), SPORT Discuss via the EBSCO interface, PubMed (Medline), Scopus, Web of Science, Embase, which were searched up to April 2023. All cohort studies reporting the risk ratio (RR) with a 95% confidence interval (CI) were included in the study. The quality assessment was done based on the Newcastle-Ottawa Scale (NOS).
resultsFinally, thirty-five cohort studies were selected for meta-analysis. Outcomes of interest included pre-eclampsia, gestational diabetes, abortion, preterm birth, infant death, and other related outcomes. Results showed that the pooled RR for incident gestational diabetes in pregnant women with choronic hepatitis B infection was 1.16 (RR: 1.16; 95% CI 1.13-1.18; I-square: 92.89%; P value: 0.00). Similarly, the association between the presence of hepatitis B infection in pregnant women and the occurrence of pre-eclampsia was 1.10 (RR: 1.10; 95% CI 1.04-1.16; I-square: 92.06%; P value: 0.00). The risk of preterm delivery in pregnant women with hepatitis B infection was 1.17 times that of pregnant women without hepatitis B infection (RR: 1.17; 95% CI 1.14-1.20; I-squared: 94.32%; P value: 0.00).
conclusionThis meta-analysis found that hepatitis B infection during pregnancy may be associated with an increased risk of gestational diabetes, preterm delivery, pre-eclampsia, and eclampsia. However, confirmation of this association, as well as the specific biological pathways involved in the association between HBV infection and pregnancy outcomes, requires further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.