Evidence map›Paper›PMID 37710287›Full record

Observational studyJournal of ovarian research2023

Effect of blastocyst shrinkage on assisted reproductive outcomes: a retrospective cohort study describing a new morphological evaluation of blastocyst pre-vitrification and post-warming.

Ayumu Ito, Yukiko Katagiri, Satoko Oigawa, Kenji Amano, Koichiro Ichizawa, Yukiko Tokuda, Mami Unagami, Masato Yoneyama, Takahiro Tsuchiya, Mami Sekiguchi and 7 more

Erratum issuedOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Ayumu ItoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan. ayumu.itou@med.toho-u.ac.jp.
Yukiko KatagiriDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Satoko OigawaReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Kenji AmanoReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Koichiro IchizawaReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Yukiko TokudaReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Mami UnagamiReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Masato YoneyamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Takahiro TsuchiyaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Mami SekiguchiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Mayuko FuruiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Kentaro NakaokaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Nahomi UmemuraDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Yuko HayashiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Yuko TamakiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Koichi NagaoReproduction Center, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-Ku, Tokyo, 143-8541, Japan.
Masahiko NakataDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, 5-21-16, Omorinishi, Ota-Ku, Tokyo, 143-0015, Japan.
Toho University Omori Medical Center · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe failure of frozen-thawed blastocysts to re-expand adequately within a few hours after warming has been reported to have a negative impact on assisted reproductive technology (ART) outcomes. However, the extent to which this failure truly affects ART outcomes has not yet been presented in a manner that is easily understandable to medical practitioners and patients. This study aimed to assess the effects of blastocyst shrinkage on ART outcomes and determine a more effective morphological evaluation approach for use in clinical settings.

methodsThis retrospective observational cohort study of frozen-thawed blastocyst transfer cycles was conducted from April 2017 to March 2022. Overall, 1,331 cycles were eligible for inclusion, of which 999 were good-quality blastocysts (GQB) and 332 were non-good-quality blastocysts (non-GQB). All frozen-thawed blastocyst transfer cycles performed during the specified study period were included in the study. Exclusion criteria were established to mitigate potential sources of bias as these cycles could impact implantations. We calculated rates and age-adjusted odds ratios of implantation, clinical pregnancy, ongoing pregnancy, and live birth of the re-expansion group, which showed sufficient expansion, and shrinkage group, which showed insufficient expansion. We also calculated the implantation, clinical pregnancy, ongoing pregnancy, and live birth rates of the re-expansion and shrinkage groups for each morphological scoring system parameter.

resultsA reduced ART outcome was observed with use of blastocysts with shrinkage after vitrification/warming. The age-adjusted odds ratios for implantation, clinical pregnancy, ongoing pregnancy, and live birth were lower in the shrinkage group than in the re-expansion group.

conclusionsThis study examined the adverse effect of blastocyst shrinkage after warming and recovery culturing on reproductive outcomes in a clinically useful manner by retrospectively examining a substantial number of frozen-thawed embryo transfer cycles. The study findings can possibly reduce concerns regarding over- or under-estimation of blastocyst implantation by allowing providers and patients to refer to the data.

Indexed as

Embryo ImplantationVitrificationBlastocystFemaleHumansLive BirthPregnancyRetrospective StudiesBlastocystCollapseEmbryo transferEmbryo vitrificationExpansionFrozen-thawed blastocyst transferMorphological evaluationShrinkShrinkageWarming

Identifiers

PMID37710287
PMCPMC10503151
OpenAlexW4386741528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.