Evidence map›Paper›PMID 37710023›Full record

ArticleParasitology research2023

Human protozoa infection and dysplasia in ulcerative colitis: a neglected aspect in a prominent disease.

Enas F Abdel Hamed, Nahed E Mostafa, Shaimaa M Farag, Mohamed N Ibrahim, Basma H Ibrahim, Hayam E Rashed, Mona Radwan, Salem Y Mohamed, Ramy El Hendawy, Eman M Fawzy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Enas F Abdel HamedDepartment of Medical Parasitology, Faculty of Medicine, Zagazig University, El Kawmia Square, Zagazig, Sharkia Governorate, Egypt. drenasfakhry@gmail.com.ORCID https://orcid.org/0000-0002-4039-2710
Nahed E MostafaDepartment of Medical Parasitology, Faculty of Medicine, Zagazig University, El Kawmia Square, Zagazig, Sharkia Governorate, Egypt.
Shaimaa M FaragDepartment of Medical Parasitology, Faculty of Medicine, Zagazig University, El Kawmia Square, Zagazig, Sharkia Governorate, Egypt.
Mohamed N IbrahimClinical Laboratories Department, College of Applied Medical Sciences, Jouf University, Qurrayat, Kingdom of Saudi Arabia.
Basma H IbrahimDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Hayam E RashedDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Mona RadwanDepartment of Community and Occupational Medicine, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Salem Y MohamedDepartment of Internal Medicine, Gastroenterology & Hepatology Unit, Zagazig University, Zagazig, Egypt.
Ramy El HendawyDepartment of Tropical Medicine, Zagazig University, Zagazig, Egypt.
Eman M FawzyDepartment of Medical Parasitology, Faculty of Medicine, Zagazig University, El Kawmia Square, Zagazig, Sharkia Governorate, Egypt.
Zagazig University · EGJouf University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chance of getting colorectal cancer (CRC) is higher in people with chronic ulcerative colitis (UC). The impact of parasitic infections on UC is underappreciated. The purpose of this study was to look into the effect of intestinal protozoal infections on the dysplastic changes generated by UC. The research included 152 adult patients with histologically confirmed UC and 152 healthy controls. Fecal samples were examined for the presence of parasites and fecal calprotectin (FC). The enzyme-linked immunosorbent assay measured serum anti-p53 antibodies (p53Abs) and metallothioneins (MTs). The advanced oxidation protein products (AOPPs) and reduced glutathione (GSH) levels were measured by a spectrophotometric method in all subjects. Serum C-reactive protein (CRP) and IL-6 were also measured. In addition, histopathological and immunohistochemical investigations of intestinal tissue were done. Our results exhibited significant increases in FC and CRP, IL-6, AOPPs, MTs, and p53Abs in ulcerative colitis patients with parasitic infections compared to those without parasites. In contrast, GSH levels showed a significant decrease in the same group compared with other groups. Histopathological and immunohistochemical assessments of intestinal tissue signified severe inflammation and strong expression of PD-L1 in patients with parasitic infections compared to others without parasitic infections. Our research indicated a greater frequency of intestinal protozoa in UC patients with elevated inflammatory and dysplastic biomarker levels. This suggests that these parasites may be involved in the etiology of chronic UC and the associated carcinogenetic process. This is the first report of a link between parasitic infections and dysplastic alterations in UC patients.

Indexed as

Colitis, UlcerativeParasitic DiseasesAdultAdvanced Oxidation Protein ProductsAntibodiesBiomarkersFecesHumansInterleukin-6Advanced Oxidation Protein ProductsAntibodiesBiomarkersInterleukin-6AOPPsDysplasiaFCMTsp53AbsPD-L1Protozoal infectionsUlcerative colitis

Identifiers

PMID37710023
PMCPMC10567919
OpenAlexW4386758341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.