Evidence map›Paper›PMID 37709991›Full record

ArticleHuman cell2023

TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.

Fubin Zhang, Tianhong Zhu, Chenghao Wu, Dongsheng Shen, Lixiao Liu, Xueqin Chen, Yutao Guan, Huiqing Ding, Xiaowen Tong

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Cancers · 2025
    Article
  3. Article
  4. TRIM28 in cancer and cancer therapy.Frontiers in genetics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fubin ZhangDepartment of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Tianhong ZhuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315010, Zhejiang Province, China.
Chenghao WuDepartment of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Dongsheng ShenDepartment of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Lixiao LiuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315010, Zhejiang Province, China.
Xueqin ChenDepartment of Traditional Medicine, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315010, Zhejiang Province, China.
Yutao GuanDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315010, Zhejiang Province, China. 2309732100@qq.com.
Huiqing DingDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315010, Zhejiang Province, China. dinghuiqing@nbdyyy.com.
Xiaowen TongDepartment of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China. tongxiaowen2022@163.com.
Ningbo University · CNTongji University · CNNingbo First Hospital · CN

Funding

Clinical Research Fund of Zhejiang Medical Association 2021ZYC-A106Consortia for Improving Medicine with Innovation and Technology 2022Z148Construction of Key Disciplines of Tongji Hospital in the Fifth cycle ZD16-FC-1Science and Technology Programs of Ningbo 202003N4289the Medical and Health Science and Technology Program of Zhejiang Province, China 2021440659the National Natural Science Foundation of China 81771560the National Natural Science Foundation of China 82071630
6 · The paper itself

Abstract

Chromobox protein homolog 8 (CBX8) is a transcriptional suppressor participated in various cancers. However, the function and mechanism of CBX8 in the progression of ovarian cancer (OC) are unclear. In this study, we found that CBX8 was upregulated in OC tissues originating from GEPIA and TNM databases, OC patients' samples from hospital, and OC cell lines. Furthermore, CBX8 knockdown by short hairpin RNA (shRNA) technology markedly inhibited proliferation and invasion, induced migration, cell cycle arrest, and apoptosis in vitro. Mechanistically, CBX8 activated PI3K/AKT/mTOR signaling pathway to take effect. In addition, TRIM28 and E2F1 were enriched in OC tissues from the TNM database and OC patients' samples similar to the results of CBX8. Correlation analysis indicated positive correlations among TRIM28, E2F1, and CBX8. E2F1 was proved to bind to the promoter regions of CBX8 and TRIM28, while TRIM28 recruited E2F1 to increase the expression of CBX8 to further increase cell viability, proliferation, and invasion, and decrease migration, apoptosis, and cell cycle progression. Finally, CBX8 or TRIM28 knockdown repressed tumor growth and metastasis of OC in vivo. Therefore, our study showed that the promoting effect of CBX8 on tumor growth and metastasis of OC was participated in the PI3K/AKT/mTOR signaling, TRIM28 and E2F1. Our findings suggested that CBX8 could serve as a potential marker and therapeutic target for OC patients.

Indexed as

Cell ProliferationE2F1 Transcription FactorNeoplasm MetastasisOvarian NeoplasmsPolycomb-Group ProteinsPolycomb Repressive Complex 1Tripartite Motif-Containing Protein 28ApoptosisCell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCBX8 protein, humanE2F1 protein, humanE2F1 Transcription FactorMTOR protein, humanPhosphatidylinositol 3-KinasesPolycomb-Group ProteinsPolycomb Repressive Complex 1Proto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesTRIM28 protein, humanTripartite Motif-Containing Protein 28CBX8Ovarian cancerPI3K/AKT/mTORProliferationTRIM28

Identifiers

PMID37709991
OpenAlexW4386732578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.