Evidence map›Paper›PMID 37709986›Full record

ArticleNature immunology2023

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8

Laure Tillé, Daniela Cropp, Mélanie Charmoy, Patrick Reichenbach, Massimo Andreatta, Tania Wyss, Gabrielle Bodley, Isaac Crespo, Sina Nassiri, Joao Lourenco and 8 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Targeting TMED4 enhances CD8Science advances · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Regulators of CD8Nature reviews. Immunology · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Laure Tillé *Department of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8163-0837
Daniela Cropp *Department of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6125-9775
Mélanie CharmoyDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Patrick ReichenbachDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Massimo AndreattaDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8036-2647
Tania WyssSIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0003-2641-0895
Gabrielle BodleyDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Isaac CrespoDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Sina NassiriDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Joao LourencoSIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Marine M LeblondDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
Cristina Lopez-RodriguezImmunology Unit, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-2311-2406
Daniel E SpeiserDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.
George CoukosDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8813-7367
Melita IrvingDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6849-7194
Santiago J CarmonaDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-2495-0671
Werner HeldDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3292-1536
Grégory VerdeilDepartment of Oncology, UNIL CHUV, University of Lausanne, Lausanne, Switzerland. gregory.verdeil@unil.ch.ORCID 0000-0001-9445-8474
Ludwig Cancer Research · CHSIB Swiss Institute of Bioinformatics · CHUniversity of Lausanne · CHUniversitat Pompeu Fabra · ES

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_182680Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_200898
6 · The paper itself

Abstract

Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer, despite obvious differences in their microenvironments. Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8

Indexed as

Lymphocytic ChoriomeningitisNeoplasmsCD8-Positive T-LymphocytesHumansLymphocytic choriomeningitis virusPersistent InfectionProgrammed Cell Death 1 ReceptorT-Cell ExhaustionTranscription FactorsTumor MicroenvironmentNFAT5 protein, humanProgrammed Cell Death 1 ReceptorTranscription Factors

Identifiers

PMID37709986
OpenAlexW4386741004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.