Evidence map›Paper›PMID 37709984›Full record

Trial reportClinical oral investigations2023

Impact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3-4, Grade C periodontitis patients: a split-mouth, randomized control study.

F Pamuk, M Lütfioğlu, T Paksoy, C Z Koyuncuoglu, N G Polat, E Cifcibasi, S Yildirim, A Kantarci

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05233501 (The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received Non-surgical Periodontal Treatment.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05233501 nacompletednot on this map

The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received Non-surgical Periodontal Treatment.

TypeinterventionalSponsorUniversity of BeykentRan2017 to 2018Enrolled15ConditionsPeriodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal InflammationArmslow level laser therapy, non-surgical periodontal treatment
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

F PamukDepartment of Oral Health Sciences, University of Leuven (KU Leuven), Leuven, Belgium. drferdapamuk@gmail.com.
M LütfioğluFaculty of Dentistry, Department of Periodontology, Ondokuz Mayis University, Samsun, Turkey.
T PaksoyHamidiye Faculty of Dentistry, Department of Periodontology, University of Health Sciences, Istanbul, Turkey.
C Z KoyuncuogluFaculty of Dentistry, Department of Periodontology, Istanbul Aydin University, Istanbul, Turkey.
N G PolatClinical Laboratory, Unit of Immunology and Allergy, Koç University Hospital, Istanbul, Turkey.
E CifcibasiFaculty of Dentistry, Department of Periodontology, Istanbul University, Istanbul, Turkey.
S YildirimFaculty of Dentistry, Department of Periodontology, Ondokuz Mayis University, Samsun, Turkey.
A KantarciForsyth Institute, 245 First Street, Cambridge, MA, 02142, USA.
Ondokuz Mayıs University · TRBeykent University · TRIstanbul Aydın University · TRIstanbul University · TRKoç University · TRSağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system. MATERIALS AND

methodsStage 3-4 Grade C periodontitis and age-gender-matched healthy individuals participated in the split-mouth study (ClinicalTrials.gov identifier, NCT05233501). The study groups were Periodontitis/NSPT (Sham); Periodontitis/NSPT + LLLT (LLLT); Healthy (Control). Following NSPT, LLLT was applied on Days 0, 2 and 7. Clinical parameters were recorded at baseline and on Day 30. Gingival crevicular fluid (GCF) was collected at baseline, on days 7, 14, and 30; tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels were measured with ELISA.

resultsClinical parameters, total GCF tPA (tPA

conclusionAdjunctive LLLT modulates the plasminogen activating system in severe periodontitis by altering GCF tPA and PAI-1 levels. CLINICAL RELEVANCE: LLLT as an adjunct to non-surgical periodontal treatment in patients with Stage 3-4 Grade C leads to reduced plasminogen activation.

Indexed as

Chronic PeriodontitisLow-Level Light TherapyGingival Crevicular FluidHumansPlasminogenPlasminogen Activator Inhibitor 1Tissue Plasminogen ActivatorPlasminogenPlasminogen Activator Inhibitor 1Tissue Plasminogen ActivatorLow-level laser therapyPeriodontitisPlasminogen activator inhibitor 1Tissue plasminogen activator

Identifiers

PMID37709984
OpenAlexW4386727617

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.