ArticleJournal of neurology2024
Characterizing cognitive function in patients with autoimmune encephalitis: an Australian prospective study.
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Investigating health related quality of life and clinical measures in autoimmune encephalitis: a systematic review.Orphanet journal of rare diseases · 2025Pooled it
- Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis (MEET): A Proof of Concept Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Trial
- Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology.Epilepsia open · 2026Article
- A qualitative exploration of patient experiences living with autoimmune encephalitis.Scientific reports · 2026Article
- Epidemiologic characteristics and postoperative complication analysis of patients with craniopharyngioma in China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Psychiatric and behavioural sequelae following encephalitis: a systematic review and meta-analysis.Brain communications · 2026Review
- Bridging Epilepsy and Cognitive Impairment: Insights from EEG and Clinical Observations in a Retrospective Case Series.Journal of personalized medicine · 2025Article
- Multimodal prognostication of autoimmune encephalitis: an Australian autoimmune encephalitis consortium study.Journal of neurology · 2025Article
- Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study.The Australian and New Zealand journal of psychiatry · 2025Article
- Hippocampal dysmetabolism contributes to cognitive loss in autoimmune encephalitis and focal temporal epilepsy.Frontiers in neurology · 2025Article
- Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms.Journal of neurology · 2024Article
- Outcome and Sequelae of Autoimmune Encephalitis.Journal of clinical neurology (Seoul, Korea) · 2024Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveThis study uses the Wechsler intelligence and memory scales to characterize the cognitive function of patients with autoimmune encephalitis (AE) in the chronic stage of the disease. AE is a group of neuroinflammatory disorders, and cognitive impairment is a significant source of chronic morbidity in these patients.
methodsFifty patients with an average disease duration of 3.2 years after diagnosis were prospectively recruited from four hospitals. They underwent a comprehensive cognitive examination using the Wechsler Abbreviated Scale of Intelligence (WASI-II), Wechsler Adult Intelligence Scale (WAIS-IV) and Wechsler Memory Scale (WMS-IV). Summary statistics were computed, and single-sample and independent-samples t tests were used to compare the cohort to normative data.
resultsThe results revealed significantly reduced performances in perceptual reasoning, processing speed, and working memory among AE patients. Seropositive AE patients exhibited below-norm processing speed, while the seronegative group showed reduced working memory and processing speed. Delayed memory performance was significantly below expectations only in seronegative patients. Pattern analysis indicated that intact cognition was the most observed outcome after AE, but significant heterogeneity was observed among the impaired patients.
conclusionsThe study identified deficits in perceptual reasoning, processing speed, and working memory among chronic AE patients. Pattern analysis highlighted positive long-term cognitive outcomes for many but varied outcomes for those with ongoing difficulties. Although severely cognitively impaired patients were not included, the findings apply to AE cohorts who attend outpatient clinical neuropsychology consultations emphasizing the need for thorough cognitive assessment. The results suggest a need for further research targeting other cognitive domains, including executive functions.
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