Evidence map›Paper›PMID 37709945›Full record

ReviewNPJ digital medicine2023

A translational perspective towards clinical AI fairness.

Mingxuan Liu, Yilin Ning, Salinelat Teixayavong, Mayli Mertens, Jie Xu, Daniel Shu Wei Ting, Lionel Tim-Ee Cheng, Jasmine Chiat Ling Ong, Zhen Ling Teo, Ting Fang Tan and 5 more

Abstract readReview
In one paragraph

Review in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. [Ethical considerations for artificial intelligence-enhanced brain-computer interface].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mingxuan Liu *Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Yilin Ning *Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-6758-4472
Salinelat TeixayavongCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Mayli MertensCentre for Ethics, Department of Philosophy, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-9883-9167
Jie XuDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, USA.
Daniel Shu Wei TingCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Lionel Tim-Ee ChengDepartment of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1068-7868
Jasmine Chiat Ling OngDepartment of Pharmacy, Singapore General Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6916-5960
Zhen Ling TeoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ting Fang TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Narrendar RaviChandranSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0001-7365-0053
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9459-9461
Leo Anthony CeliLaboratory for Computational Physiology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6712-6626
Marcus Eng Hock OngProgramme in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Nan LiuCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. liu.nan@duke-nus.edu.sg.ORCID http://orcid.org/0000-0003-3610-4883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) has demonstrated the ability to extract insights from data, but the fairness of such data-driven insights remains a concern in high-stakes fields. Despite extensive developments, issues of AI fairness in clinical contexts have not been adequately addressed. A fair model is normally expected to perform equally across subgroups defined by sensitive variables (e.g., age, gender/sex, race/ethnicity, socio-economic status, etc.). Various fairness measurements have been developed to detect differences between subgroups as evidence of bias, and bias mitigation methods are designed to reduce the differences detected. This perspective of fairness, however, is misaligned with some key considerations in clinical contexts. The set of sensitive variables used in healthcare applications must be carefully examined for relevance and justified by clear clinical motivations. In addition, clinical AI fairness should closely investigate the ethical implications of fairness measurements (e.g., potential conflicts between group- and individual-level fairness) to select suitable and objective metrics. Generally defining AI fairness as "equality" is not necessarily reasonable in clinical settings, as differences may have clinical justifications and do not indicate biases. Instead, "equity" would be an appropriate objective of clinical AI fairness. Moreover, clinical feedback is essential to developing fair and well-performing AI models, and efforts should be made to actively involve clinicians in the process. The adaptation of AI fairness towards healthcare is not self-evident due to misalignments between technical developments and clinical considerations. Multidisciplinary collaboration between AI researchers, clinicians, and ethicists is necessary to bridge the gap and translate AI fairness into real-life benefits.

Identifiers

PMID37709945
PMCPMC10502051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.