ReviewScientific reports2023
Effects of C-reactive protein trajectories of critically ill patients with sepsis on in-hospital mortality rate.
Review in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Observational
- Dynamic Co-Evolution of C-Reactive Protein and Albumin in Early Sepsis: A Group-Based Dual-Trajectory Analysis for Risk Stratification.Journal of cellular and molecular medicine · 2026Article
- Beyond a Single Snapshot: Inflammatory Markers in Acute-on-chronic Liver Failure.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Predictive Value of C-Reactive Protein-Albumin-Lymphocyte Index for Multiple Organ Failure Syndrome in Elderly Patients with Sepsis.Biochemical genetics · 2026Article
- Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.BMC anesthesiology · 2026Article
- Blood biomarker trajectories in ICU-directed prediction models - A scoping review.The EPMA journal · 2026Review
- Age- and Sex-Dependent Interpretation of C-Reactive Protein Cutoffs: A Sixteen-Year Large-Scale Clinical Laboratory Data Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- C-Reactive Protein Trajectories by Summary Metric Across the Coronavirus-2019 Period: A 16-Year Interrupted Time-Series Analysis (2008-2023).Diagnostics (Basel, Switzerland) · 2026Article
- Clinical and inflammatory biomarkers predicting emergency surgical management decisions and postoperative outcomes in complicated colon cancer.Journal of medicine and life · 2026Article
- Infections in Pediatric Palliative Care Units: Clinical and Microbiological Perspectives from a Single Center.Antibiotics (Basel, Switzerland) · 2026Article
- Dynamic BUN patterns in the ICU: risk stratification and prognosis following cardiac surgery.Journal of cardiothoracic surgery · 2026Article
- Machine Learning Model for Sepsis Prediction in Prolonged and Chronic Critical Illness: Development and Validation Using Retrospective Real-World ICU Data.Journal of clinical medicine · 2026Article
- Dynamic serum chloride trajectories predict short- and long-term mortality in patients with malignancies: a retrospective cohort study with external validation.Frontiers in oncology · 2026Article
- Serial C-Reactive Protein Measurements for Prognostication and Antimicrobial Decision-Making in ICU Sepsis Patients: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Early enteral nutrition and dynamic metabolic-inflammatory trajectories in sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Early inflammatory and nutritional marker recovery patterns and short-term outcomes in critically ill older adults: a 72-h landmark cohort study.Frontiers in medicine · 2026Article
- Achieving ≥70% of energy requirements during early enteral nutrition and short-term inflammatory-metabolic profiles in critically ill patients with sepsis: a prospective cohort study.Frontiers in nutrition · 2026Article
- Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis.Frontiers in pharmacology · 2026Review
- Systemic Inflammation and its association with functional impairment and mortality in patients with disease-related malnutrition: findings from the AFEDIN cohort.Frontiers in nutrition · 2026Article
- IHIT-BED: an interpretable transformer approach using unbiased hematology analyzer impedance data for early identification of bacteremia in emergency department.Bioinformatics advances · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, a life-threatening condition caused by an inflammatory response to systemic infection, results in a significant social burden and healthcare costs. This study aimed to investigate the relationship between the C-reactive protein (CRP) trajectories of patients with sepsis in the intensive care unit (ICU) and the in-hospital mortality rate. We reviewed 1464 patients with sepsis treated in the ICU of Dongyang People's Hospital from 2010 to 2020 and used latent growth mixture modeling to divide the patients into four classes according to CRP trajectory (intermediate, gradually increasing, persistently high, and persistently low CRP levels). We found that patients with intermediate and persistently high CRP levels had the lowest (18.1%) and highest (32.6%) in-hospital mortality rates, respectively. Multiple logistic regression analysis showed that patients with persistently high (odds ratio [OR] = 2.19, 95% confidence interval [CI] = 1.55-3.11) and persistently low (OR = 1.41, 95% CI = 1.03-1.94) CRP levels had a higher risk of in-hospital mortality than patients with intermediate CRP levels. In conclusion, in-hospital mortality rates among patients with sepsis differ according to the CRP trajectory, with patients with intermediate CRP levels having the lowest mortality rate. Further research on the underlying mechanisms is warranted.
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