Evidence map›Paper›PMID 37709856›Full record

ArticleScientific reports2023

Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain.

Sherrye T Glaser, Kalani Jayanetti, Saida Oubraim, Andrew Hillowe, Elena Frank, Jason Jong, Liqun Wang, Hehe Wang, Iwao Ojima, Samir Haj-Dahmane and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Neurons run on fat.npj metabolic health and disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sherrye T Glaser *Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Kalani Jayanetti *Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.
Saida Oubraim *Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Andrew HilloweDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Elena FrankDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Jason JongDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Liqun WangDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Hehe WangDepartment of Chemistry, Stony Brook University, Stony Brook, NY, USA.
Iwao OjimaDepartment of Chemistry, Stony Brook University, Stony Brook, NY, USA.
Samir Haj-DahmaneDepartment of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA. Sh38@Buffalo.edu.
Martin KaczochaDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA. Martin.Kaczocha@Stonybrook.edu.
Stony Brook School · USStony Brook University · USUniversity at Buffalo, State University of New York · USKingsborough Community College · US

Funding

FABPs: Novel Roles in Pain and InflammationR01DA035949 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN · 2014 to 2022
$3.0M
Synaptic transport of endocannabinoids in the brainR01MH122461 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI HAJ-DAHMANE, SAMIR, KACZOCHA, MARTIN · 2021 to 2024
$2.3M
Synaptic transport of endocannabinoids in the brain R56MH122461 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI HAJ-DAHMANE, SAMIR, KACZOCHA, MARTIN · 2020 to 2020
$679k
NIDA NIH HHS R01 DA035949NIMH NIH HHS R01 MH122461NIMH NIH HHS R56 MH122461
6 · The paper itself

Abstract

Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles and nuclear receptors. More recently, FABP5 has emerged as a key regulator of synaptic endocannabinoid signaling, suggesting that FABPs may broadly regulate the signaling of neuroactive lipids in the brain. Herein, we demonstrate that brain-expressed FABPs (FABP3, FABP5, and FABP7) interact with epoxyeicosatrienoic acids (EETs) and the peroxisome proliferator-activated receptor gamma agonist 15-deoxy-Δ

Indexed as

BrainFatty Acid-Binding ProteinsCell CommunicationEicosanoidsFatty Acid-Binding Protein 7Glutamic AcidEicosanoidsFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlutamic Acid

Identifiers

PMID37709856
PMCPMC10502087
OpenAlexW4386744688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.