ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Inhibition of Dopamine Neurons Prevents Incentive Value Encoding of a Reward Cue: With Revelations from Deep Phenotyping.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 25 citations in OpenAlex.
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- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
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- Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens.bioRxiv : the preprint server for biology · 2026Article
- Phasic dopamine drives conditioned responding beyond its role in learning.bioRxiv : the preprint server for biology · 2026Article
- Chronic semaglutide treatment enhances the incentive motivational value of a small food reward and associated cue in male and female rats.Psychopharmacology · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Dopamine receptor sensitivity, cocaine-induced behaviors, and Pavlovian conditioned approach in male rats.Psychopharmacology · 2026Article
- Beyond dopamine: Broader neuromodulatory contributions in sign- and goal-tracking.Psychopharmacology · 2026Review
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Phasic dopamine encodes persistent attraction to reward cues.bioRxiv : the preprint server for biology · 2025Article
- Dopamine receptor sensitivity and Pavlovian conditioned approach.Research square · 2025Article
- Article
- Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
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- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The survival of an organism is dependent on its ability to respond to cues in the environment. Such cues can attain control over behavior as a function of the value ascribed to them. Some individuals have an inherent tendency to attribute reward-paired cues with incentive motivational value, or incentive salience. For these individuals, termed sign-trackers, a discrete cue that precedes reward delivery becomes attractive and desirable in its own right. Prior work suggests that the behavior of sign-trackers is dopamine-dependent, and cue-elicited dopamine in the NAc is believed to encode the incentive value of reward cues. Here we exploited the temporal resolution of optogenetics to determine whether selective inhibition of ventral tegmental area (VTA) dopamine neurons during cue presentation attenuates the propensity to sign-track. Using male tyrosine hydroxylase
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.