Evidence map›Paper›PMID 37709338›Full record

ArticleBMJ open2023

Cardiovascular risk factors in coeliac disease (ARCTIC): a protocol of multicentre series of studies.

Zsófia Vereczkei, Marcell Imrei, Zsolt Szakács, Bálint Kővári, Veronika Papp, Zsuzsanna Lénárt, Tímea Berki, Balázs Szirmay, Nelli Farkas, Márta Balaskó and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05530070 (Cardiovascular Risk Factors in Coeliac Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05530070 narecruitingnot on this map

Cardiovascular Risk Factors in Coeliac Disease: a Series of Studies

TypeinterventionalSponsorUniversity of PecsRan2022 to 2026Enrolled190ConditionsCoeliac DiseaseArmsDietary intervention, Standard of care, Cardiovascular risk-related parameters
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zsófia VereczkeiInstitute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.ORCID 0000-0002-8144-4628
Marcell ImreiCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Zsolt SzakácsFirst Department of Medicine, Medical School, University of Pecs, Pecs, Hungary.
Bálint KőváriFirst Department of Medicine, Medical School, University of Pecs, Pecs, Hungary.
Veronika PappDepartment of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary.
Zsuzsanna LénártFirst Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Tímea BerkiDepartment of Immunology and Biotechnology, Medical School, University of Pecs, Pecs, Hungary.
Balázs SzirmayDepartment of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary.
Nelli FarkasInstitute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Márta BalaskóInstitute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Tamás HabonFirst Department of Medicine, Medical School, University of Pecs, Pecs, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.ORCID 0000-0003-0399-7259
Judit BajorFirst Department of Medicine, Medical School, University of Pecs, Pecs, Hungary bajor.judit@pte.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is only limited and controversial information available on the cardiovascular (CV) risk in coeliac disease (CD). In this study, we plan to investigate the body composition and CV risk-related metabolic parameters at the diagnosis of CD and on a gluten-free diet in a Hungarian cohort of patients with CD. METHODS AND ANALYSIS: This study consists of two case-control studies and a prospective cohort study, involving newly diagnosed and treated patients with CD with age and sex-matched non-CD control subjects with an allocation ratio of 1:1. CD-related symptoms, quality of life, quality of the diet and CV risk will be assessed with questionnaires. Our primary outcomes are body composition parameters, which will be estimated with InBody 770 device. Secondary outcomes are CV-risk related metabolic parameters (eg, serum lipids, haemoglobin A1c, homeostatic model assessment index, liver enzymes, homocysteine, interleukin 6, galectin-3) and enteral hormones (leptin, ghrelin, adiponectin) measured from venous blood samples for all participants. Fatty liver disease will be assessed by transabdominal ultrasonography. In statistical analysis, descriptive and comparative statistics will be performed. With this study, we aim to draw attention to the often neglected metabolic and CV aspect of the management of CD. Findings may help to identify parameters to be optimised and reassessed during follow-up in patients with CD. ETHICS AND DISSEMINATION: The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (27521-5/2022/EÜIG). Findings will be disseminated at research conferences and in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05530070.

Indexed as

Cardiovascular DiseasesCeliac DiseaseHeart Disease Risk FactorsHumansMulticenter Studies as TopicProspective StudiesQuality of LifeRisk Factorscardiac epidemiologycoeliac diseasenutrition & dieteticsprotocols & guidelines

Identifiers

PMID37709338
PMCPMC10503320

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.