Evidence map›Paper›PMID 37709319›Full record

Observational studyBMJ open2023

Risk factors for neonatal mortality: an observational cohort study in Sarlahi district of rural southern Nepal.

Tingting Yan, Luke C Mullany, Seema Subedi, Elizabeth A Hazel, Subarna K Khatry, Diwakar Mohan, Scott Zeger, James M Tielsch, Steven C LeClerq, Joanne Katz

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01177111 (Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01177111 phase3completednot on this map

Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2010 to 2017Enrolled29,260ConditionsNeonatal Mortality, Neonatal SepsisArmsSunflower seed oil, Mustard seed oil
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting YanDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-6667-4348
Luke C MullanyDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Seema SubediDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-6360-3998
Elizabeth A HazelDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-9176-3278
Subarna K KhatryDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Diwakar MohanDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Scott ZegerDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
James M TielschDepartment of Global Health, George Washington University School of Public Health and Health Services, Washington, DC, USA.
Steven C LeClerqDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Joanne KatzDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA jkatz1@jhu.edu.

Funding

Impact of Sunflower Oil Massage on Neonatal Mortality in NepalR01HD060712 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MULLANY, LUKE C · 2009 to 2013
$2.9M
Prioritization of modifiable risk factors for adverse pregnancy outcomes and neonatal mortality in rural NepalR01HD092411 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KATZ, JOANNE · 2018 to 2020
$822k
NICHD NIH HHS R01 HD060712NICHD NIH HHS R01 HD092411
6 · The paper itself

Abstract

objectivesTo assess the association between maternal characteristics, adverse birth outcomes (small-for-gestational-age (SGA) and/or preterm) and neonatal mortality in rural Nepal.

designThis is a secondary observational analysis to identify risk factors for neonatal mortality, using data from a randomised trial to assess the impact of newborn massage with different oils on neonatal mortality in Sarlahi district, Nepal.

settingRural Sarlahi district, Nepal.

participants40 119 pregnant women enrolled from 9 September 2010 to 16 January 2017. MAIN OUTCOME: The outcome variable is neonatal death. Cox regression was used to estimate adjusted Hazard Ratios (aHRs) to assess the association between adverse birth outcomes and neonatal mortality.

resultsThere were 32 004 live births and 998 neonatal deaths. SGA and/or preterm birth was strongly associated with increased neonatal mortality: SGA and preterm (aHR: 7.09, 95% CI: (4.44 to 11.31)), SGA and term/post-term (aHR: 2.12, 95% CI: (1.58 to 2.86)), appropriate-for-gestational-age/large-for-gestational-age and preterm (aHR: 3.23, 95% CI: (2.30 to 4.54)). Neonatal mortality was increased with a history of prior child deaths (aHR: 1.53, 95% CI: (1.24 to 1.87)), being a twin or triplet (aHR: 5.64, 95% CI: (4.25 to 7.48)), births at health posts/clinics or in hospital (aHR: 1.34, 95% CI: (1.13 to 1.58)) and on the way to facilities or outdoors (aHR: 2.26, 95% CI: (1.57 to 3.26)). Risk was lower with increasing maternal height from <145 cm to 145-150 cm (aHR: 0.78, 95% CI: (0.65 to 0.94)) to ≥150 cm (aHR: 0.57, 95% CI: (0.47 to 0.68)), four or more antenatal care (ANC) visits (aHR: 0.67, 95% CI: (0.53 to 0.86)) and education >5 years (aHR: 0.75, 95% CI: (0.62 to 0.92)).

conclusionSGA and/or preterm birth are strongly associated with increased neonatal mortality. To reduce neonatal mortality, interventions that prevent SGA and preterm births by promoting ANC and facility delivery, and care of high-risk infants after birth should be tested. TRIAL REGISTRATION NUMBER: NCT01177111.

Indexed as

Perinatal DeathPremature BirthChildCohort StudiesFemaleHumansInfantInfant MortalityInfant, NewbornNepalPregnancyRisk FactorsEpidemiologyFactor Analysis, StatisticalNEONATOLOGYPrimary PreventionPublic healthRisk Factors

Identifiers

PMID37709319
PMCPMC10503364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.