Evidence map›Paper›PMID 37709308›Full record

ArticleBMJ open2023

Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults.

Kevin Josey, Rachel Nethery, Aayush Visaria, Benjamin Bates, Poonam Gandhi, Ashwaghosha Parthasarathi, Melanie Rua, David Robinson, Soko Setoguchi

Abstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A Drug-Environment Interaction Between PMPharmacoepidemiology and drug safety · 2026
    Article
  2. Excess risk of heat-related hospitalization associated with temperature and PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin JoseyDepartment of Biostatistics, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-2490-6272
Rachel NetheryDepartment of Biostatistics, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Aayush VisariaDepartment of Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.ORCID 0000-0002-2170-212X
Benjamin BatesDepartment of Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Poonam GandhiRutgers University Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.
Ashwaghosha ParthasarathiRutgers University Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.
Melanie RuaRutgers University Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.
David RobinsonDepartment of Geography, Rutgers The State University of New Jersey, New Brunswick, New Jersey, USA.
Soko SetoguchiDepartment of Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA soko.setoguchi@rutgers.edu.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Disease Outcomes iN Older adults under extreme Heat, AiR pollution and Medication use (DO-NO-HARM)R01AG060232 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI SETOGUCHI IWATA, SOKO · 2019 to 2023
$3.0M
Causal machine learning methods for studying the effects of environmental exposures on childhood cancer using natural experimentsK01ES032458 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI NETHERY, RACHEL C · 2021 to 2023
$417k
NIA NIH HHS R01 AG060232NIEHS NIH HHS K01 ES032458NIEHS NIH HHS P30 ES005022NIEHS NIH HHS T32 ES007142
6 · The paper itself

Abstract

objectiveTo evaluate the synergistic effects created by fine particulate matter (PM DESIGN AND

settingA retrospective cohort study using a US nationwide administrative healthcare claims database.

participantsA 50% random sample of participants with high-risk conditions for CTE from the 2008-2016 Medicare Fee-for-Service population. EXPOSURES: Corticosteroid therapy and seasonal-average PM

main outcome measuresIncidences of myocardial infarction or acute coronary syndrome (MI/ACS), ischaemic stroke or transient ischaemic attack, heart failure (HF), venous thromboembolism, atrial fibrillation and all-cause mortality. We assessed additive interactions between PM

resultsAmong the 1 936 786 individuals in the high CTE risk cohort (mean age 76.8, 40.0% male, 87.4% white), the mean PM

conclusionPM

Indexed as

Air PollutionBrain IschemiaHeart FailureStrokeVenous ThromboembolismAdrenal Cortex HormonesAgedFemaleHumansMaleMedicareRetrospective StudiesUnited StatesAdrenal Cortex Hormonescardiac epidemiologyclinical pharmacologyheart failuremyocardial infarctionstatistics & research methodsstroke

Identifiers

PMID37709308
PMCPMC10503335

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.