Evidence map›Paper›PMID 37709282›Full record

ArticleAdvanced healthcare materials2023

Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.

Carmen J Gil, Connor J Evans, Lan Li, Alex J Allphin, Martin L Tomov, Linqi Jin, Merlyn Vargas, Boeun Hwang, Jing Wang, Victor Putaturo and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Image-Guided Cardiac Regeneration via a 3D Bioprinted Vascular Patch with Built-in CT Visibility.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Carmen J GilWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Connor J EvansDepartment of Aerospace and Mechanical Engineering, Bioengineering Graduate Program, Materials Science and Engineering Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA.
Lan LiDepartment of Aerospace and Mechanical Engineering, Bioengineering Graduate Program, Materials Science and Engineering Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA.
Alex J AllphinQuantitative Imaging and Analysis Lab, Department of Radiology, Duke University, Durham, NC, 27710, USA.
Martin L TomovWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Linqi JinWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Merlyn VargasDepartment of Bioengineering, George Mason University, Manassas, VA, 22030, USA.
Boeun HwangWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Jing WangDepartment of Physics, Emory University, Atlanta, GA, 30322, USA.
Victor PutaturoWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Gabriella KabboulWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Anjum S AlamDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Roshni K NandwaniDepartment of Quantitative Theory and Methods, Emory University College of Arts and Sciences, Atlanta, GA, 30322, USA.
Yuxiao WuDepartment of Quantitative Theory and Methods, Emory University College of Arts and Sciences, Atlanta, GA, 30322, USA.
Asif SushmitBiomedical Imaging Center, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Travis FultonResearch Service, VA Medical Center, Decatur, GA, 30033, USA.
Ming ShenDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Jarred M KaiserResearch Service, VA Medical Center, Decatur, GA, 30033, USA.
Liqun NingWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Remi VenezianoDepartment of Bioengineering, George Mason University, Manassas, VA, 22030, USA.
Nick WilletWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Ge WangBiomedical Imaging Center, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Hicham DrissiResearch Service, VA Medical Center, Decatur, GA, 30033, USA.
Eric R WeeksDepartment of Physics, Emory University, Atlanta, GA, 30322, USA.
Holly D Bauser-HeatonWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.
Cristian T BadeaQuantitative Imaging and Analysis Lab, Department of Radiology, Duke University, Durham, NC, 27710, USA.
Ryan K RoederDepartment of Aerospace and Mechanical Engineering, Bioengineering Graduate Program, Materials Science and Engineering Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA.
Vahid SerpooshanWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, 30322, USA.ORCID 0000-0002-5304-095X

Funding

Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Leveraging 3D bioprinted organoid constructs to pattern and model human brain developmentR01MH126195 · NIMH · EMORY UNIVERSITY · PI SERPOOSHAN, VAHID, SLOAN, STEVEN A · 2021 to 2025
$3.3M
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart diseaseRF1AG070149 · NIA · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2021 to 2022
$2.1M
Acquisition of MARS photon-counting micro-CT scannerS10OD026811 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI WANG, GE · 2019 to 2019
$752k
Spatial and Temporal Role of the Runx3 Transcription Factor in Secondary Fracture HealingI01BX004708 · VA · VETERANS HEALTH ADMINISTRATION · PI DRISSI, MOULAY HICHAM · 2020 to 2023
–
CMA: Cartilage Repair Strategies to Alleviate Arthritic Pain (CaRe AP): Novel cell-based therapies to increase functional outcomes and alleviate pain in preclinical models of osteoarthritisI01BX004878 · VA · VETERANS HEALTH ADMINISTRATION · PI DRISSI, MOULAY HICHAM · 2021 to 2024
–
BLRD VA I01 BX004708BLRD VA I01 BX004878NHLBI NIH HHS R01 HL131017NIA NIH HHS RF1 AG070149NIH HHS 1S10OD026811NIH HHS MH126195NIH HHS R01 HL131017NIH HHS RF1 AG070149-01NIH HHS RF1 AG070149-01S1NIH HHS S10 OD026811NIMH NIH HHS R01 MH126195
6 · The paper itself

Abstract

3D bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lack of quantitative and noninvasive techniques to longitudinally track the function of implants has hampered clinical applications of bioprinted scaffolds. In this study, multimaterial 3D bioprinting, engineered nanoparticles (NPs), and spectral photon-counting computed tomography (PCCT) technologies are integrated for the aim of developing a new precision medicine approach to custom-engineer scaffolds with traceability. Multiple CT-visible hydrogel-based bioinks, containing distinct molecular (iodine and gadolinium) and NP (iodine-loaded liposome, gold, methacrylated gold (AuMA), and Gd

Indexed as

BioprintingIodineAnimalsMicePrinting, Three-DimensionalReproducibility of ResultsTissue EngineeringTissue ScaffoldsTomography, X-Ray ComputedIodine3D bioprintingbioinkscontrast agentslongitudinal quantitative imagingnanoparticlesphoton-counting computed tomographytissue engineering scaffolds

Identifiers

PMID37709282
PMCPMC10842604

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.