Evidence map›Paper›PMID 37708852›Full record

ArticleCell host & microbe2023

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8

Hiroshi Takata, Julie L Mitchell, Julian Pacheco, Amélie Pagliuzza, Suteeraporn Pinyakorn, Supranee Buranapraditkun, Carlo Sacdalan, Louise Leyre, Sam Nathanson, Juyeon C Kakazu and 14 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Persistent CD8Frontiers in immunology · 2026
    Article
  10. HIV Nef amplifies mechanical heterogeneity to promote immune evasion.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. CD8medRxiv : the preprint server for health sciences · 2025
    Article
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 3 countries.

Hiroshi TakataVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Julie L MitchellVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Julian PachecoVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Amélie PagliuzzaCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC, Canada.
Suteeraporn PinyakornU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Supranee BuranapraditkunFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Carlo SacdalanSEARCH Research Foundation, Bangkok, Thailand; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Louise LeyreCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC, Canada.
Sam NathansonVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Juyeon C KakazuU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Jintana IntasanSEARCH Research Foundation, Bangkok, Thailand.
Peeriya PrueksakaewSEARCH Research Foundation, Bangkok, Thailand.
Nitiya ChomcheySEARCH Research Foundation, Bangkok, Thailand.
Nittaya PhanuphakInstitute of HIV Research and Innovation, Bangkok, Thailand.
Mark de SouzaSEARCH Research Foundation, Bangkok, Thailand.
Elias K HaddadDepartment of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Morgane RollandU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Sodsai TovanabutraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Sandhya VasanU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Denise C HsuU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Nicolas ChomontCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC, Canada.
Lydie TrautmannVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA. Electronic address: ltrautmann@global-id.org.
RV254/SEARCH010
RV304/SEARCH013
Henry M. Jackson Foundation · USCentre Hospitalier de l’Université de Montréal · CAChulalongkorn University · THOregon Health & Science University · USDrexel University · USHIV Netherlands Australia Thailand Research Collaboration · TH

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
Preservation of adaptive immunity leads to HIV control upon treatment cessation.R01AI108433 · NIAID · VGTI FLORIDA · PI VASAN, SANDHYA · 2014 to 2018
$3.6M
Critical Role of Cytotoxic T Cells in HIV NeuropathogenesisR01MH106466 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI PICKER, LOUIS J., SPUDICH, SERENA S · 2016 to 2020
$2.8M
NIAID NIH HHS R01 AI108433NIAID NIH HHS UM1 AI164560NIMH NIH HHS R01 MH106466
6 · The paper itself

Abstract

Before initiation of antiretroviral therapy (ART), HIV-specific CD8

Indexed as

CD8-Positive T-LymphocytesGene Products, vifCell DifferentiationHumansProvirusesRNAGene Products, vifRNAantiretroviral therapyCD8 T cellscell differentiationHIVHIV reservoir

Identifiers

PMID37708852
PMCPMC10564289
OpenAlexW4386708524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.