Evidence map›Paper›PMID 37708746›Full record

ArticleThe American journal of cardiology2023

Left Atrial Strain and Incident Atrial Fibrillation in Older Adults.

Carlo Mannina, Kazato Ito, Zhezhen Jin, Yuriko Yoshida, Cesare Russo, Koki Nakanishi, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Marco R Di Tullio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Observational
  3. Article
  4. Echocardiographic strain imaging and progression of atrial fibrillation in low-risk individuals.International journal of cardiology. Heart & vasculature · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Left Atrial Function and Incident Heart Failure in Older Adults.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Carlo ManninaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Kazato ItoDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Zhezhen JinDepartment of Cardiovascular Medicine, the University of Tokyo, Tokyo, Japan.
Yuriko YoshidaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Cesare RussoDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Koki NakanishiDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Mitchell S V ElkindDepartment of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, New York; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Tatjana RundekDepartment of Neurology, Evelyn F. McKnight Brain Institute; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida; Clinical and Translational Science Institute, Miller School of Medicine, University of Miami, Miami, Florida.
Shunichi HommaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Marco R Di TullioDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York. Electronic address: md42@cumc.columbia.edu.
Columbia University · USAllen Institute for Brain Science · USMount Sinai Beth Israel · USThe University of Tokyo · JP

Funding

Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
ARCH PLAQUES AND STROKE IN AN ETHNICALLY MIXED COMMUNITYR01NS036286 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DI TULLIO, MARCO R · 1997 to 2009
$3.4M
NINDS NIH HHS R01 NS036286NINDS NIH HHS R37 NS029993
6 · The paper itself

Abstract

Atrial fibrillation (AF) is frequent in older adults and associated with left atrial (LA) dysfunction. LA strain (LAε) and LA strain rate (LASR) may detect subclinical LA disease. We investigated whether reduced LAε and LASR predict new-onset AF in older adults without history of AF or stroke. LAε and LASR were assessed by speckle-tracking echocardiography in 824 participants from the community-based Cardiovascular Abnormalities and Brain Lesions study. Positive longitudinal LAε and LASR during ventricular systole, LASR during early ventricular diastole, and LASR during LA contraction were measured. Cause-specific hazards regression model evaluated the association of LAε and LASR with incident AF, adjusting for pertinent covariates. The mean age was 71.1 ± 9.2 years (313 men, 511 women). During a mean follow-up of 10.9 years, new-onset AF occurred in 105 participants (12.7%). Lower LAε and LASR at baseline were observed in patients with new-onset AF (all p <0.01). In multivariable analysis, positive longitudinal LAε (adjusted hazard ratio [HR] per SD decrease 2.05, confidence interval [CI] 1.24 to 3.36) and LASR during LA contraction (HR per SD increase 2.24, CI 1.37 to 3.65) remained associated with new-onset AF, independently of LA volumes and left ventricular function. Along with positive longitudinal LAε, reduced LASR during ventricular systole predicted AF in participants with LA volume below the median value (HR 2.54, CI 1.10 to 6.09), whereas reduced LASR during LA contraction predicted AF in participants with larger LA (HR 2.35, CI 1.31 to 4.23). In conclusion, reduced positive longitudinal LAε and LASR predict new-onset AF in older adults regardless of LA size and may improve AF risk stratification.

Indexed as

Atrial AppendageAtrial FibrillationAgedAged, 80 and overEchocardiographyFemaleHeart AtriaHumansMaleMiddle AgedVentricular Function, Leftatrial fibrillationatrial myopathycardiovascular preventionelderlyleft atrial strainspeckle-tracking echocardiography

Identifiers

PMID37708746
PMCPMC10592022
OpenAlexW4386691536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.