Evidence map›Paper›PMID 37708739›Full record

ArticleNeurobiology of aging2023

White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum.

Meral A Tubi, Koral Wheeler, Elizabeth Matsiyevskiy, Matthew Hapenney, Wendy J Mack, Helena C Chui, Kevin King, Paul M Thompson, Meredith N Braskie, for Alzheimer’s Disease Neuroimaging Initiative

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Meral A TubiImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Koral WheelerImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Elizabeth MatsiyevskiyImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Matthew HapenneyImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Helena C ChuiDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kevin KingDepartment of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Meredith N BraskieImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Electronic address: braskie@usc.edu.
for Alzheimer’s Disease Neuroimaging Initiative
University of Southern California · USBarrow Neurological Institute · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
Revision Supplement: Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progressionR01AG058162 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BILLINGER, SANDRA A, CHUI, HELENA CHANG · 2018 to 2022
$11.5M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FRANZ, CAROL ELAINE · 2018 to 2022
$11.5M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s DiseaseT32AG058507 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2018 to 2026
$2.1M
Predoctoral Training in Interdisciplinary NeurosciencesT32MH111360 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZEVIN, JASON D · 2016 to 2020
$1.3M
VEGF's Relationship to Brain Aging Biomarkers and CognitionF31AG059356 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TUBI, MERAL · 2018 to 2020
$135k
Department of Defense W81XWH-12–2-0012NIA NIH HHS F31 AG059356NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058162NIA NIH HHS RF1 AG041915NIA NIH HHS T32 AG058507NIA NIH HHS U01 AG024904NIMH NIH HHS T32 MH111360
6 · The paper itself

Abstract

In older adults with abnormal levels of Alzheimer's disease neuropathology, lower cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGF) levels are associated with lower [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET) signal, but whether this association is (1) specific to VEGF or broadly driven by vascular inflammation, or (2) modified by vascular risk (e.g., white matter hyperintensities [WMHs]) remains unknown. To address this and build upon our past work, we evaluated whether 5 CSF vascular inflammation biomarkers (vascular cell adhesion molecule 1, VEGF, C-reactive protein, fibrinogen, and von Willebrand factor)-previously associated with CSF amyloid levels-were related to FDG-PET signal and whether WMH volume modified these associations in 158 Alzheimer's Disease Neuroimaging Initiative participants (55-90 years old, 39 cognitively normal, 80 mild cognitive impairment, 39 Alzheimer's disease). We defined regions both by cortical boundary and by the 3 major vascular territories: anterior, middle, and posterior cerebral arteries. We found that WMH volume had interactive effects with CSF biomarkers (VEGF and C-reactive protein) on FDG-PET throughout the cortex in both vascular territories and conventionally defined regions of interest.

Indexed as

Alzheimer DiseaseCognitive DysfunctionWhite MatterAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrainC-Reactive ProteinFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingPositron-Emission TomographyVascular Endothelial Growth Factor AAmyloid beta-PeptidesBiomarkersC-Reactive ProteinFluorodeoxyglucose F18Vascular Endothelial Growth Factor ACRPGlucose metabolismVascular territoriesVEGFWhite matter hyperintensities

Identifiers

PMID37708739
PMCPMC10843575
OpenAlexW4385741071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.