ArticleEuropean heart journal. Acute cardiovascular care2023
Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study.
Article in European heart journal. Acute cardiovascular care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Predictors of high-grade atrioventricular block recovery in Takotsubo cardiomyopathy: a systematic review of case reports.Open heart · 2026Pooled it
- A novel parameter for risk stratification in patients with takotsubo syndrome.American heart journal plus : cardiology research and practice · 2026Article
- Sinus Node Dysfunction in Takotsubo Syndrome: Illustrating Incomplete Recovery.JACC. Case reports · 2026Article
- Association between neutrophil percentage to albumin ratio and mortality in takotsubo syndrome patients: analysis of the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- When the Beat Breaks the Heart: A Case of Arrhythmia-Induced Mid-ventricular Takotsubo Cardiomyopathy.Cureus · 2026Article
- Physical triggers in takotsubo syndrome: a high-risk phenotype? insights from the eVOLUTION registry.European heart journal. Cardiovascular Imaging · 2026Observational
- Takotsubo syndrome presenting as ventricular fibrillation cardiopulmonary arrest coupled with complete heart block.Journal of cardiology cases · 2026Article
- Association Between ECG Findings on Presentation and Outcomes in Patients with Takotsubo Syndrome.Journal of clinical medicine · 2025Article
- Takotsubo Cardiomyopathy: An Exploration of the Intersection Between Stress, Coronary Dysfunction, and Cardiac Outcomes.Reviews in cardiovascular medicine · 2025Review
- When Is the Broken Heart Most Dangerous? Assessing Risk Factors to Predict Inpatient Death in Takotsubo Cardiomyopathy: Analysis of the National Inpatient Sample for 2021.Journal of the American Heart Association · 2025Article
- Prognostic relevance of arrhythmic and QTc burden in takotsubo cardiomyopathy: A systematic review and meta-analysis.Journal of arrhythmia · 2025Article
- [Bradyarrhythmia causing takotsubo syndrome: a chicken and egg situation].Archivos de cardiologia de Mexico · 2025Article
- Article
- Neurologic Disease-related Takotsubo Syndrome and Its As-yet-unidentified Etiology.Internal medicine (Tokyo, Japan) · 2024Article
- Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges)Balkan medical journal · 2024Article
- Takotsubo Syndrome and Gender Differences: Exploring Pathophysiological Mechanisms and Clinical Differences for a Personalized Approach in Patient Management.Journal of clinical medicine · 2024Review
- Takotsubo Syndrome and Coronary Artery Disease: Which Came First-The Chicken or the Egg?Journal of cardiovascular development and disease · 2024Review
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6 authors at 3 institutions in 1 country.
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Abstract
aimsArrhythmia is a major complication of Takotsubo syndrome (TTS). However, its incidence, management, and prognostic impact remain to be elucidated in a large cohort. METHODS AND
resultsWe retrospectively identified 16 713 patients hospitalized for TTS between July 2010 and March 2021 from the Japanese Diagnosis Procedure Combination database. Serious arrhythmias were defined as ventricular tachycardia/fibrillation (VT/VF), 2nd-/3rd-degree atrioventricular block (AVB), sick sinus syndrome (SSS), or unspecified arrhythmias requiring device treatment. Patient characteristics and outcomes were compared based on the occurrence of serious arrhythmias. The overall incidence proportion of serious arrhythmias was 6.2% (n = 1036; 449 VT/VF, 283 2nd-/3rd-degree AVB, 133 SSS, 55 multiple arrhythmias, 116 others), which remained stable over 11 years. The arrhythmia group was younger, more often male, and exhibited greater impairment in activities of daily living (ADLs) and consciousness than the non-arrhythmia group. Although crude in-hospital mortality was higher in the arrhythmia group (9.6% vs. 5.0%, P < 0.001), the significant association between arrhythmias and mortality disappeared after adjustment for confounders (odds ratio = 1.15, 95% confidence interval = 0.90-1.49). Meanwhile, age, sex, ADLs, consciousness level, and Charlson comorbidity index were significantly associated with mortality. In the arrhythmia group, 254 (24.5%) patients received pacemakers (18.4%) or defibrillators (6.1%), which were implanted at a median of 8 and 19 days after admission, respectively.
conclusionArrhythmias are not uncommon in TTS. Patients' background characteristics, rather than arrhythmia itself, may be associated with in-hospital mortality. Given the reversibility of cardiac dysfunction in TTS, there may be unnecessary device implantations for arrhythmias occurring as sequelae to TTS, warranting further investigations.
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