SynthesisPLoS neglected tropical diseases2023
Better efficacy of triple antibiotics therapy for human brucellosis: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of comparative clinical studies on antibiotic treatment of brucellosis.Scientific reports · 2024Pooled it
- Updated therapeutic options for human brucellosis: A systematic review and network meta-analysis of randomized controlled trials.PLoS neglected tropical diseases · 2024Pooled it
- Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Brucellosis-related pancytopenia: a diagnostic and therapeutic challenge case report from an endemic region.Iranian journal of microbiology · 2026Article
- Hepatic brucelloma with initially negative antibodies: Diagnostic challenges in an endemic region.IDCases · 2026Article
- Brucella Infection of the Sternoclavicular Joint with Innovative Localized Drug Delivery: A Case Report and Review of the Literature.Orthopedic research and reviews · 2026Article
- Design of a Prospective Human-Animal Cohort Study to Evaluate the Role of Camels and Other Livestock Species in the Transmission ofInternational journal of environmental research and public health · 2025Article
- Development and validation of a clinico-biological score for Brucella spondylitis: a two-center study.BMC infectious diseases · 2025Article
- Bioinformatic analysis of brucellosis and construction of a diagnostic model based on key genes.Scientific reports · 2025Article
- Renal manifestations of brucellosis: a case report.Journal of medical case reports · 2025Article
- Effectiveness and Safety of Dual Versus Triple Antibiotic Therapy for Treating Brucellosis Infection: A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2025Article
- Comparative analysis of clinical features of brucellosis in Kashi and Guangzhou: a retrospective multicentre study.BMC infectious diseases · 2025Article
- Unraveling brucellosis: advances in pathogenesis, diagnostic strategies, therapeutic innovations, and public health perspectives.Frontiers in medicine · 2025Review
- Concomitant Treatment with Doxycycline and Rifampicin in Balb/c Mice Infected withPharmaceuticals (Basel, Switzerland) · 2024Article
- Mapping the Global Landscape of Antibiotic-Resistant Brucellosis Research: An LDA Topic Modeling and Text Analysis.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe treatment of brucellosis suffers from a high recurrence rate and drug resistance. Our study researched the differences in efficacy and side effects between triple antibiotics therapy and dual antibiotics therapy in the treatment of brucellosis through a systematic review and meta-analysis.
methodsWe searched 4 English electronic databases and 2 Chinese electronic databases for randomized controlled trials and cohort studies published through September 2022 on the use of triple antibiotics versus dual antibiotics in the treatment of brucellosis. Overall outcome indicators were therapeutic failure rate, relapse rate, overall therapeutic failure rate, and side effect rate. Relative risk (RR) and 95% confidence intervals (95% CIs) were used as summary statistics. A fixed-effects model was used to combine the overall effect sizes.
resultsThe meta-analysis included 15 studies consisting of 11 randomized controlled trials and 4 cohort studies. Triple antibiotics showed better efficacy than dual antibiotics in a comparison of 3 overall outcome indicators (therapeutic failure rate (RR 0.42; 95% CI 0.30 to 0.59 heterogeneity P = 0.29, I2 = 15%), relapse rate (RR 0.29; 95% CI 0.18 to 0.45 heterogeneity P = 0.88, I2 = 0%), and overall therapeutic failure rate (RR 0.37; 95% CI 0.28 to 0.48 heterogeneity P = 0.35, I2 = 9%)). The incidence of side effects in patients with brucellosis treated with triple antibiotics was not significantly different from that in brucellosis patients treated with dual antibiotics (RR 0.85; 95% CI 0.67 to 1.06 heterogeneity P = 0.1, I2 = 35%). Sensitivity analyses showed robust results and Peter's test showed no publication bias. The results of subgroup analyses for the research type, drugs, and type of brucellosis were largely consistent with the overall outcome indicators, indicating the reliability and robustness of the overall results.
conclusionsIn the treatment of brucellosis, triple antibiotics have better efficacy than dual antibiotics and do not increase the incidence of side effects.
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