Evidence map›Paper›PMID 37707757›Full record

ReviewCurrent osteoporosis reports2023

The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy.

Varun S Venkatesh, Tian Nie, Jeffrey D Zajac, Mathis Grossmann, Rachel A Davey

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current osteoporosis reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. A novel model to study the impact of gender-affirming therapy on bone in young male mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Varun S VenkateshDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, 3084, Australia.
Tian NieDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, 3084, Australia.
Jeffrey D ZajacDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, 3084, Australia.
Mathis GrossmannDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, 3084, Australia.
Rachel A DaveyDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, 3084, Australia. r.davey@unimelb.edu.au.ORCID 0000-0001-5121-0209
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo summarise the evidence regarding the effects of gender-affirming hormone therapy (GAHT) on bone health in transgender people, to identify key knowledge gaps and how these gaps can be addressed using preclinical rodent models. RECENT

findingsSex hormones play a critical role in bone physiology, yet there is a paucity of research regarding the effects of GAHT on bone microstructure and fracture risk in transgender individuals. The controlled clinical studies required to yield fracture data are unethical to conduct making clinically translatable preclinical research of the utmost importance. Novel genetic and surgical preclinical models have yielded significant mechanistic insight into the roles of sex steroids on skeletal integrity. Preclinical models of GAHT have the potential inform clinical approaches to preserve skeletal integrity and prevent fractures in transgender people undergoing GAHT. This review highlights the key considerations required to ensure the information gained from preclinical models of GAHT are informative.

Indexed as

Fractures, BoneTransgender PersonsBone DensityFemaleHormonesHumansMaleHormonesBone microstructureBone strengthGender-affirming hormone therapy (GAHT)Preclinical rodent modelsTransgender

Identifiers

PMID37707757
PMCPMC10724092
OpenAlexW4386726841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.