Evidence map›Paper›PMID 37707204›Full record

ArticleMicrobiology spectrum2023

Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions.

António A R Camarão, Olivia Luise Gern, Felix Stegmann, Felix Mulenge, Bibiana Costa, Babak Saremi, Klaus Jung, Bernd Lepenies, Ulrich Kalinke, Imke Steffen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

António A R Camarão *Institute of Biochemistry, University of Veterinary Medicine Hannover , Hannover, Germany.ORCID 0000-0002-0614-4908
Olivia Luise Gern *Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School , Hannover, Germany.ORCID 0000-0001-6638-2206
Felix StegmannResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover , Hannover, Germany.
Felix MulengeInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School , Hannover, Germany.
Bibiana CostaInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School , Hannover, Germany.
Babak SaremiInstitute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover , Hannover, Germany.
Klaus JungInstitute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover , Hannover, Germany.
Bernd LepeniesResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover , Hannover, Germany.
Ulrich KalinkeInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School , Hannover, Germany.
Imke SteffenInstitute of Biochemistry, University of Veterinary Medicine Hannover , Hannover, Germany.ORCID 0000-0001-6592-0332
University of Veterinary Medicine Hannover, Foundation · DEMedizinische Hochschule Hannover · DE

Funding

Bundesministerium für Bildung und Forschung (BMBF) 01KI1719Deutsche Forschungsgemeinschaft (DFG) 398066876/GRK 2485/1
6 · The paper itself

Abstract

importanceThe effective initiation of protective host immune responses controls the outcome of infection, and dysfunctional T-cell responses have previously been associated with symptomatic human flavivirus infections. We demonstrate that secreted flavivirus NS1 proteins modulate innate immune responses of uninfected bystander cells. In particular, sNS1 markedly reduced the capacity of dendritic cells to stimulate T-cell responses upon activation. Hence, by modulating cellular host responses that are required for effective antigen presentation and initiation of adaptive immunity, sNS1 proteins may contribute to severe outcomes of flavivirus disease.

Indexed as

dendritic cellsflavivirusimmune evasioninnate immunitynon-structural protein 1tick-borne encephalitis virusWest Nile virus

Identifiers

PMID37707204
PMCPMC10581055
OpenAlexW4386726675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.