Evidence map›Paper›PMID 37706329›Full record

ArticleCancer medicine2023

Single-nucleotide polymorphism at alcohol dehydrogenase 1B: A susceptible gene marker in oro-/hypopharyngeal cancers from genome-wide association study.

Hui-Tzu Chien, Chia-Lung Tsai, Chi-Kuan Young, Yun-Shien Lee, Chun-Ta Liao, Chih-Ching Yeh, Angel Chao, Kai-Lun Cho, Ching-Han Chen, Shiang-Fu Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hui-Tzu ChienDepartment of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Chia-Lung TsaiGenomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Chi-Kuan YoungDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.
Yun-Shien LeeDepartment of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Chun-Ta LiaoDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.ORCID 0000-0002-3677-4249
Chih-Ching YehMaster Program in Applied Molecular Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0001-6483-1100
Angel ChaoDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0003-3834-2754
Kai-Lun ChoDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Ching-Han ChenSchool of Medicine, Chang Gung Medical College, Chang Gung University, Taoyuan, Taiwan.
Shiang-Fu HuangDepartment of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.ORCID 0000-0003-3582-9938
Chang Gung Memorial Hospital · TWChang Gung University · TWChang Gung University of Science and Technology · TWTaipei Medical University Hospital · TW

Funding

Chang Gung Medical Foundation CMRPG3J0593Chang Gung Medical Foundation CMRPG3L0861Chang Gung Medical Foundation CMRPG3M1101Chang Gung Medical Foundation CMRPG3M1102Ministry of Science and Technology, Taiwan MOST 110-2314-B-182-045-MY3
6 · The paper itself

Abstract

introductionIn the era of precision preventive medicine, susceptible genetic markers for oro-/hypopharyngeal squamous cell carcinoma (OPSCC) have been investigated for genome-wide associations. MATERIALS AND

methodsA case-control study including 659 male head and neck squamous cell carcinoma (HNSCC) patients, including 331 oropharyngeal cancer, treated between March 1996 and December 2016 and 2400 normal controls was performed. A single-nucleotide polymorphism (SNP) array was used to determine genetic loci that increase susceptibility to OPSCC.

resultsWe analyzed the allele frequencies of 664,994 autosomal SNPs in 659 HNSCC cases; 7 SNPs scattered in loci of chromosomes 5, 7, 9, 11, and 19 were significant in genome-wide association analysis (Pc < 1.0669 × 10

conclusionADH1B was an important genetic locus that significantly correlated with the development of OPSCCs and patient survival.

Indexed as

Alcohol DehydrogenaseBiomarkers, TumorGenetic Predisposition to DiseaseOropharyngeal NeoplasmsPolymorphism, Single NucleotideSquamous Cell Carcinoma of Head and NeckAdultAgedCase-Control StudiesGene FrequencyGenome-Wide Association StudyHumansMaleMiddle AgedADH1B protein, humanAlcohol DehydrogenaseBiomarkers, Tumoralcohol dehydrogenase 1Baldehyde dehydrogenase 2genome-wide association studyhead and neck canceroropharyngeal cancer

Identifiers

PMID37706329
PMCPMC10557853
OpenAlexW4386725589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.