Evidence map›Paper›PMID 37706204›Full record

ArticleMaterials today. Bio2023

Multifunctional polysaccharide composited microneedle for oral ulcers healing.

Yiyu Zeng, Yijun Gao, Liming He, Wenhui Ge, Junhui Liu, Yi Yu, Xiaoyan Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  18. Progressive microneedles for targeting and intelligent drug delivery.Asian journal of pharmaceutical sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiyu ZengDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
Yijun GaoDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
Liming HeDepartment of Stomatology, Changsha Stomatological Hospital, Changsha, 410004, PR China.
Wenhui GeDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
Junhui LiuXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410000, PR China.
Yi YuDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
Xiaoyan XieDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral ulcers have periodicity and recurrence, and the etiology and causative mechanisms remain unclear; therefore, it is difficult to treat oral ulcers effectively. Current clinical treatment methods mainly include pain relief and administration of anti-inflammatories to prevent secondary infections and a prolonged recurrence cycle. However, these traditional treatment methods are administered independently and are susceptible to muscle movements and constant salivary secretion in the mouth, resulting in ineffective drug functioning. Therefore, development of a novel treatment to reduce wound infection and accelerate wound healing for oral ulcers is required for effective treatment. Herein, we report a multifunctional polysaccharide composite microneedle patch based on hyaluronic acid (HA) and hydroxypropyl trimethyl ammonium chloride chitosan (HACC) loaded with dexamethasone (DXMS) and basic fibroblast growth factor (bFGF) for oral ulcer healing. DXMS and bFGF encapsulated the HA tip portion of the microneedle patch, endowing the microneedle patches with anti-inflammatory and angiogenic properties. HACC was applied to the back of the microneedle patch, adding antibacterial properties. The experimental results indicated that the prepared dressings exhibited good antibacterial activity and effectively promoted cell migration growth and angiogenesis. More importantly, animal experiments have shown that multifunctional microneedle patches can effectively promote oral ulcer healing. Thus, these novel multifunctional polysaccharide composite microneedle patches have great potential for oral ulcers treatment.

Indexed as

Hyaluronic acidMicroneedleOral ulcersPolysaccharideWound healing

Identifiers

PMID37706204
PMCPMC10495667

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.