ArticleiScience2023
Increased interhemispheric functional connectivity during non-dominant hand movement in right-handed subjects.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Time-Dependent Enhancement of Motor Dexterity and Cerebellar Function via Premotor-Cerebellar Associative Stimulation.The European journal of neuroscience · 2026Article
- Neural mechanisms of handedness for precision drawing: hand-dependent engagement of cortical networks for bimanual control and tool use.bioRxiv : the preprint server for biology · 2025Article
- Transfer of motor learning is associated with patterns of activity in the default mode network.PLoS biology · 2025Article
- Alteration of prefrontal functional connectivity in preclinical Alzheimer's disease: an fNIRS study.Frontiers in aging neuroscience · 2025Article
- Comparison of local activation, functional connectivity, and structural connectivity in the N-back task.Frontiers in neuroscience · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand preference is one of the behavioral expressions of lateralization in the brain. Previous fMRI studies showed the activation in several regions including the motor cortex and the cerebellum during single-hand movement. However, functional connectivity related to hand preference has not been investigated. Here, we used the generalized psychophysiological interaction (gPPI) approach to investigate the alteration of functional connectivity during single-hand movement from the resting state in right-hand subjects. The functional connectivity in interhemispheric motor-related regions including the supplementary motor area, the precentral gyrus, and the cerebellum was significantly increased during non-dominant hand movement, while functional connectivity was not increased during dominant hand movement. The general linear model (GLM) showed activation in contralateral supplementary motor area, contralateral precentral gyrus, and ipsilateral cerebellum during right- or left-hand movement. These results indicate that a combination of GLM and gPPI analysis can detect the lateralization of hand preference more clearly.
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Registered trials
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