Evidence map›Paper›PMID 37705211›Full record

Observational studyClinical and translational science2023

A pilot study to identify pharmacogenomic and clinical risk factors associated with opioid related falls and adverse effects in older adults.

Sophia Sheikh, Rosemarie Fernandez, Carmen Smotherman, Jennifer Brailsford, Taimour Langaee, Esteban Velasquez, Morgan Henson, Taylor Munson, Andrew Bertrand, Phyllis Hendry and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.ORCID 0000-0003-1939-3126
Rosemarie FernandezDepartment of Emergency Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0001-9588-4424
Carmen SmothermanCenter for Data Solutions, University of Florida, College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Jennifer BrailsfordCenter for Data Solutions, University of Florida, College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Taimour LangaeeDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0001-5040-6365
Esteban VelasquezDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Morgan HensonDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.ORCID 0000-0001-7882-426X
Taylor MunsonDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Andrew BertrandDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Phyllis HendryDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.ORCID 0000-0002-4881-5159
Stephen AntonDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5020-5280
Roger B FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0002-7699-8183
Larisa H CavallariDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-7184-5292
University of Florida · USAmerican Association of Colleges of Pharmacy · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
SOCIAL SUPPORT OF CAREGIVERS FOR DEMENTIA PATIENTSF33AG005654 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI SOKOLOVSKY, JAY H · 1994 to 1994
–
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIA NIH HHS F33 AG005654
6 · The paper itself

Abstract

Given the high prevalence of pain in older adults and current trends in opioid prescribing, inclusion of genetic information in risk prediction tools may improve opioid risk assessment. Our objectives were to (1) determine the feasibility of recruiting socioeconomically disadvantaged and racially diverse middle aged and older adult populations for a study seeking to identify risk factors for opioid-related falls and other serious adverse effects and (2) explore potential associations between the Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (CIP-RIOSORD) risk class and other patient factors with falls and serious opioid adverse effects. This was an observational study of 44 participants discharged home from the emergency department with an opioid prescription for acute pain and followed for 30 days. We found pain interference may predict opioid-related falls or serious adverse effects within older, opioid-treated patients. If validated, pain interference may prove to be a beneficial marker for risk stratification of older adults initiated on opioids for acute pain.

Indexed as

Acute PainAnalgesics, OpioidAgedHumansMiddle AgedPharmacogeneticsPilot ProjectsPractice Patterns, Physicians'Risk FactorsAnalgesics, Opioid

Identifiers

PMID37705211
PMCPMC10651658
OpenAlexW4386725476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.