ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
A Mechanically Resilient and Tissue-Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 145 citations in OpenAlex.
- Application of hydrogel technologies in the treatment of musculoskeletal disorders.Chinese medical journal · 2026Review
- Article
- Lentinan-Based Multifunctional Composite Hydrogel for Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Microsphere-Loaded and Borax-Reinforced Polyacrylic Acid (PAA)/Polyvinyl Alcohol (PVA) Hydrogels Incorporating Tannic Acid: Ultra-High Toughness and Antibacterial Properties for Artificial Intelligence Skin.Macromolecular bioscience · 2026Article
- Layered Graphene/Hydrogel-Based Multi-Modal Sensors Enabled by Ion-Electron Synergistic Conduction.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Plant derived tannic acid-based tissue adhesives: From mechanism to advanced design.Acta biomaterialia · 2026Review
- Sprayable Hydrogel Dressings in Wound-Healing Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Innovative applications of multidimensional engineered hydrogels in wound healing.Journal of advanced research · 2026Review
- Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion.Nature communications · 2026Article
- Covalently Immobilized Neomycin in Self-Healing Hydrogel for Nonleaching Antibacterial Dressing in Diabetic Wound Healing.ACS omega · 2026Article
- Immunomodulatory hydrogel reprograms IL-17/NF-κB signaling to drive regeneration in diabetic wounds.Materials today. Bio · 2026Article
- Rapidly photocrosslinkable charged silk-based hydrogel for emergency hemostasis and multifunctional wound therapy.Bioactive materials · 2026Article
- Carnosic acid-loaded stimuli-responsive hydrogel promotes wound healing through PGP-1 mediated immune remodeling.Journal of nanobiotechnology · 2026Article
- Smart Composite Hydrogels for Monitoring and Managing Chronic Wounds.Gels (Basel, Switzerland) · 2026Review
- Bioinspired and smart material systems for auricular cartilage engineering: toward microenvironment-responsive and self-regulating scaffolds.Regenerative biomaterials · 2026Review
- Dual-mode rapid hemostatic materials composed of gelatin and carboxymethyl cellulose for non-compressible bleeding in spinal surgery.Regenerative biomaterials · 2026Article
- Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.Results and problems in cell differentiation · 2026Review
- Precision targeting of FDX1-mediated cuproptosis by a ROS-responsive hydrogel for myocardial ischemia-reperfusion injury treatment.Theranostics · 2026Article
- Bioadhesive hydrogels as immunomodulatory interfaces for chronic wound healing: from microenvironmental regulation mechanism to engineering strategies.Burns & trauma · 2026Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Hydrogels are used in wound dressings because of their tissue-like softness and biocompatibility. However, the clinical translation of hydrogels remains challenging because of their long-term stability, water swellability, and poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self-healable, nonswellable, conformally tissue-adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self-healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Furthermore, the hydrophobic moieties of TA provide a water-shielding effect, rendering the hydrogel nonswellable. A simple chemical modification to the hydrogel further strengthens its interfacial adhesion with tissues (shear strength of ≈31 kPa). Interestingly, the TA also can serve as an effective hemostatic (blood-clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The antibacterial effects of the hydrogel are tested against Escherichia coli and Staphylococcus aureus. Finally, the hydrogel is prepared in patch form and applied to a mouse model to test in vivo biocompatibility and hemostatic performances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.