Evidence map›Paper›PMID 37705105›Full record

ArticleAddiction science & clinical practice2023

Early COVID-Related pandemic impacts and subsequent opioid outcomes among persons receiving medication for opioid use disorder: a secondary data analysis of a Type-3 hybrid trial.

Tim Janssen, Bryan R Garner, Julia Yermash, Kimberly R Yap, Sara J Becker

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction science & clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03931174 (Implementing Contingency Management in Opioid Treatment Centers Across New England), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03931174 nacompletednot on this map

Implementing Contingency Management in Opioid Treatment Centers Across New England: A Type 3 Hybrid Trial

TypeinterventionalSponsorBrown UniversityRan2019 to 2024Enrolled780ConditionsOpioid-use DisorderArmsAddiction Technology Transfer Center (ATTC) Training Strategy, Enhanced Addiction Technology Transfer Center (E-ATTC) Training Strategy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tim JanssenDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, Rhode Island, 02903, USA. tim_janssen@brown.edu.ORCID http://orcid.org/0000-0003-0012-2609
Bryan R GarnerDepartment of Internal Medicine, Ohio State University College of Medicine, 2050 Kenny Road, Columbus, OH, 43221, USA.
Julia YermashDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, Rhode Island, 02903, USA.
Kimberly R YapCenter for Dissemination and Implementation Science, Northwestern University, 633 North St Clair, Chicago, IL, 60611, USA.
Sara J BeckerCenter for Dissemination and Implementation Science, Northwestern University, 633 North St Clair, Chicago, IL, 60611, USA.
Brown University · USNorthwestern University · USThe Ohio State University · US

Funding

Implementing contingency management in opioid treatment centers across New England: A hybrid type 3 trialR01DA046941 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BECKER, SARA, GARNER, BRYAN R · 2018 to 2022
$3.6M
Informing treatment adaptation based on the interplay between behavioral undercontrol and context: an event-level studyK01AA026335 · NIAAA · BROWN UNIVERSITY · PI JANSSEN, TIM · 2018 to 2022
$904k
NIAAA NIH HHS K01 AA026335NIDA NIH HHS R01 DA046941
6 · The paper itself

Abstract

backgroundOpioid overdoses have continued to increase since the start of the COVID-19 pandemic. The pathways through which the COVID-19 pandemic has affected trajectories of opioid use and opioid-related problems are largely unknown. Using the Epidemic-Pandemic Impacts Inventory (EPII), a novel instrument that assess pandemic-related impacts across multiple life domains, we tested the hypothesis that COVID-related impacts (on e.g., interpersonal conflict, employment, infection exposure, and emotional health) experienced in the early months of the pandemic would predict changes in opioid use and opioid-related problems at follow-up.

methodsThis analysis was embedded within a cluster randomized type 3 implementation-effectiveness hybrid trial that had enrolled 188 patients across eight opioid treatments prior to the start of the pandemic. Participants had all been recently inducted on medication for opioid use disorder and were actively receiving treatment. Participants reported on their opioid use and opioid-related problems at baseline and 3-, 6-, and 9-month post-baseline assessments. Between May and August 2020, participants were sent an optional invitation to complete the EPII.

resultsOne hundred thirty-three respondents completed the EPII and 129 had sufficient data to analyze the EPII and at least one subsequent follow-up. In logistic and zero-inflated negative binomial analyses adjusting for covariates, each endorsed pandemic impact in the interpersonal conflict domain was associated with 67% increased odds of endorsement of any opioid use, and each impact in the employment and infection exposure-domains was associated with 25% and 75% increases in number of endorsed opioid-related problems, respectively.

conclusionsMitigating the effect of the pandemic on patients' interpersonal relationships and employment, and promoting greater infection control in opioid treatment programs, could be protective against negative opioid-related outcomes. Trial registration The present study describes secondary data analysis on a previously registered clinical trial: clinicaltrials.gov/ct2/show/NCT03931174.

Indexed as

COVID-19Opioid-Related DisordersAnalgesics, OpioidHumansPandemicsSecondary Data AnalysisAnalgesics, OpioidCOVID-19Epidemic-pandemic impacts inventoryOpioidsOpioid use disorder

Identifiers

PMID37705105
PMCPMC10500804
OpenAlexW4386726647

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.