SynthesisHormones (Athens, Greece)2023
Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis.
Synthesis in Hormones (Athens, Greece), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Effect of probiotics and paraprobiotics on patients with sleep disorders and sub-healthy sleep conditions: a meta-analysis of randomized controlled trials.Frontiers in neurology · 2024Pooled it
- Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.Journal of translational medicine · 2025Trial
- Expert consensus on osteoporosis risk management in patients with sleep disorders.Bone research · 2026Review
- Sleep-Disordered Breathing and Decreased Bone Mineral Density: Masking Effects of Body Mass Index.Obesity facts · 2026Article
- Vitamin D Deficiency Is Associated with a Higher 5-Year Risk of Obstructive Sleep Apnea and CPAP Use in Older Adults: An Anchor-Based Network Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Comparative Diagnostic Performance of Serum α-Klotho and FGF-23 in Predicting Obstructive Sleep Apnea Severity: A Novel Biomarker Approach.Journal of clinical medicine · 2026Article
- Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Indoor Employment as a Factor Associated with Vitamin D Levels in Obstructive Sleep Apnoea Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
- Predictors of vitamin D deficiency and quality of life in obese patients with obstructive sleep apnea.Scientific reports · 2026Article
- Vitamin D deficiency and risk of heart failure in patients with obstructive sleep apnea: a cohort analysis.Frontiers in nutrition · 2026Article
- Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- The mediating effect of BMI in serum vitamin D related sleep deprivation based on the NHANES database.Frontiers in nutrition · 2025Article
- Vitamin D deficiency and subsequent risk of obstructive sleep apnea: a multi-institutional retrospective study.Frontiers in nutrition · 2025Article
- Article
- Association between Serum Vitamin D Status and Circadian Syndrome: A Cross-Sectional Study.Nutrients · 2024Article
- Impact of Obstructive Sleep Apnea and Sympathetic Nervous System on Cardiac Health: A Comprehensive Review.Journal of cardiovascular development and disease · 2024Review
- Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea.Life (Basel, Switzerland) · 2024Article
- Using music to soothe our patients, measuring hair cortisol, and machine learning in diabetes: Prof. Batrinos would have been very happy!Hormones (Athens, Greece) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
purposeObstructive sleep apnea (OSA) is a chronic, sleep-related breathing disorder which leads to increased cardiovascular risks. Vitamin D deficiency is associated with various cardiometabolic complications, including increased cardiovascular morbidity and mortality. We aimed to analyze the difference in serum 25-hydroxyvitamin D (25-OHD) level, prevalence of vitamin D insufficiency and deficiency, and the effect of CPAP treatment on serum 25-OHD levels among adult patients with OSA.
methodsWe pooled data from 18 observational studies involving 5592 individuals. Baseline parameters that might have contributed to the significant differences observed were also analyzed.
resultsPatients with OSA had significantly lower serum 25-OHD levels (pooled d + - 0.74 [95% CI: - 1.19 to - 0.28], p < 0.01) and higher prevalence of vitamin D deficiency (pooled log (odds ratio) 0.98 [95% CI: 0.30 to 1.67], p < 0.01) compared to those without OSA. Subgroup analysis demonstrated that these differences were significant only in moderate OSA and severe OSA. Neither age nor BMI nor geographical latitude contributed significantly to the differences observed in serum 25-OHD levels. The use of CPAP did not lead to significant changes in serum 25-OHD levels.
conclusionPatients with OSA have lower serum 25-OHD levels with a higher prevalence of vitamin D deficiency, regardless of age or BMI, pointing to an independent association between vitamin D and OSA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.