SynthesisClinical oral investigations2023
Influence of sodium hypochlorite on cyclic fatigue resistance of nickel-titanium instruments: A systematic review and meta-analysis of in vitro studies.
Synthesis in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Mapping risk of bias criteria in systematic reviews of in vitro endodontic studies: an umbrella review.Evidence-based dentistry · 2025Pooled it
- Mechanical and elemental comparison of EndoStar and One Curve nickel-titanium endodontic files: AnJournal of conservative dentistry and endodontics · 2026Article
- Beyond S-cross section design: mechanical properties, metallurgical features and shaping ability of two nickel-titanium rotary instruments in double curved canals.Clinical oral investigations · 2026Article
- Do irrigating solutions influence the cyclic fatigue resistance of heat-treated NiTi instruments? an in vitro study.The Saudi dental journal · 2026Article
- Fracture Risk of Endodontic Files: Clinical Analysis of Reciproc and X1 Blue After Multiple Uses.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2025Article
- A Safety Limit of the Number of Artificial Canals That Can Be Prepared by Two Rotary Endodontic Files Operated at Two Different Speeds: A Novel Approach.Bioengineering (Basel, Switzerland) · 2025Article
- Impact of the reuse of reciprocating instruments on cyclic fatigue resistance: WaveOne Gold and R-Motion.Journal of clinical and experimental dentistry · 2025Article
- Effect of Endodontic Irrigants on the Cyclic Fatigue Resistance of Nickel-Titanium Rotary Instruments: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Quantitative Evaluation of Debris Removal from NiTi Rotary Endodontic Instruments After Different Cleaning Procedures.Dentistry journal · 2025Article
- Enhancement of Fracture Toughness of NiTi Alloy by Controlling Grain Size Gradient.Nanomaterials (Basel, Switzerland) · 2025Article
- Evaluation of Cyclic Fatigue Resistance of Novel Replica-Like Instruments in Static Test Model.Applied bionics and biomechanics · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis systematic review/meta-analysis investigated the influence of NaOCl on cyclic fatigue resistance of endodontic NiTi instruments. MATERIALS AND
methodsA systematic search until July 2022 in PubMed/MEDLINE, Embase, Scopus, Web of Science, SciELO, Cochrane Library, and grey literature was conducted. According to the PECOS strategy, only in vitro studies evaluating the effects of NaOCl on the cyclic fatigue resistance of NiTi instruments were eligible. Cyclic fatigue resistance was the primary outcome. A modified Joanna Briggs Institute's Checklist was used for risk of bias assessment.
resultsOf the 2,445 records screened, 37 studies were included. Most studies used simulated canals made of stainless-steel block with severe to moderate curvatures. NaOCl concentration varied from 1-6%, mainly at 37 °C. Regarding fatigue resistance, 23 studies using 1.2% to 6% NaOCl showed a reduction in the resistance compared to the control groups, especially when pre-heated. Four meta-analyses were performed according to the tested NiTi systems. The meta-analyses indicated that the PTU F2 files had higher reduction of fatigue resistance after exposure to 5.25% NaOCl; no differences between NaOCl and no immersion were observed for Reciproc R25, WaveOne 25.08, and WaveOne Gold Primary files. Included studies had low risk of bias.
conclusionNaOCl appears to reduce cyclic fatigue resistance of certain NiTi files, especially when they are pre-heated, particularly in conventional NiTi files compared to some heat-treated instruments. It is possible that the temperature of the solution may have a greater influence on resistance than NaOCl itself. Important to note that an overall tendency toward no significant influence was observed among various systems. CLINICAL RELEVANCE: Precautions are necessary when a pre-heated high-concentration NaOCl is used to enhance its properties during root canal preparation, mainly using conventional wire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.