Evidence map›Paper›PMID 37704831›Full record

ArticleNeuromolecular medicine2023

CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.

Xianxin Kang, Yanhui Cao, Guodong Sun, Dongsheng Fei, Kai Kang, Xianglin Meng, Mingyan Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. MALAT1-miR-20b-5p-P2RX7 Axis RegulatesVeterinary sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xianxin KangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Yanhui CaoDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Guodong SunDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Dongsheng FeiDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Kai KangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Xianglin MengDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China.
Mingyan ZhaoDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Nangang District, Harbin, 150000, Heilongjiang Province, People's Republic of China. icuzhaomingyan@163.com.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

Basic research business fees and research projects of provincial higher education institutions in Heilongjiang Province 2019/KYYWF/0341
6 · The paper itself

Abstract

Activated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown alleviated MCAO/R-induced cerebral injury in mice. circPTP4A2 knockdown promoted microglia M2 polarization after OGD/R. circPTP4A2 promoted YTHDF1 expression by sponging miR-20b-5p. The promoting effect of circPTP4A2 knockdown on microglia M2 polarization was abrogated by miR-20b-5p inhibition. YTHDF1 activated the NF-κB pathway by increasing TIMP2 mRNA stability and expression. circPTP4A2 downregulation promoted microglia M2 polarization to inhibit IS development by regulating the miR-20b-5p/YTHDF1/TIMP2/NF-κB axis.

Indexed as

Ischemic StrokeMicroRNAsAnimalsHumansImmediate-Early ProteinsMiceMicrogliaNF-kappa BProtein Tyrosine PhosphatasesRNA-Binding ProteinsTissue Inhibitor of Metalloproteinase-2Immediate-Early ProteinsMicroRNAsNF-kappa BProtein Tyrosine PhosphatasesPtp4a2 protein, mouseRNA-Binding ProteinsTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2YTHDF1 protein, humanCircPTP4A2Ischemic strokeMicroglia polarizationMiR-20b-5pTIMP2

Identifiers

PMID37704831
OpenAlexW4386697291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.