Evidence map›Paper›PMID 37704799›Full record

ArticleInfectious diseases and therapy2023

Clusters of SARS-CoV-2 Infection Across Six Schools for Students with Intellectual and Developmental Disabilities.

Michael Gemmell, Tyler Walsh, Michael Sherby, Adwoa Imbeah, Kelly Bono, Megan Baldenweck, Christina Gurnett, Jason G Newland

Registry-linked trialAbstract read
In one paragraph

Article in Infectious diseases and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04565509 (Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04565509 nacompletednot on this map

Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

TypeinterventionalSponsorWashington University School of MedicineRan2020 to 2024Enrolled1,143ConditionsCovid19, Intellectual Disability, Developmental Disability, Child Development DisorderArmsStandard Messaging, Enhanced Messaging, COVID-19 Testing, Focus Groups, Fuzzy Cognitive Mapping
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael GemmellDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA. m.gemmell@wustl.edu.
Tyler WalshDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA. tyler.walsh@wustl.edu.ORCID http://orcid.org/0009-0002-7704-6149
Michael SherbyDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Adwoa ImbeahDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Kelly BonoDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Megan BaldenweckDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Christina GurnettDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Jason G NewlandDivision of Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
WUIDDRC and KKI Safe Return to SchoolOT2HD107556 · NICHD · WASHINGTON UNIVERSITY · PI GURNETT, CHRISTINA, KALB, LUTHER · 2021 to 2021
$2.7M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NICHD NIH HHS OT2 HD107556NICHD NIH HHS P50 HD103525
6 · The paper itself

Abstract

introductionIndividuals with intellectual and developmental disabilities are at increased risk for adverse outcomes from coronavirus disease 2019. Clusters of COVID-19 infections can be used to track SARS-CoV-2 transmission. This is particularly important in environments frequently used for individuals with intellectual and developmental disabilities, such as schools. The objective of this study was to compare the number of clusters of student and staff cases identified during three distinct periods (pre-Delta, Delta, and Omicron) of the COVID-19 pandemic.

methodsWeekly COVID-19 testing occurred from November 23, 2020 to May 27, 2022 during three phases of the COVID-19 pandemic: pre-Delta, Delta, and Omicron. Structured interviews were conducted with positive cases to determine if they contracted COVID-19 in the school environment, and interviews with school administrators responsible for contact tracing determined school-based clusters.

results160 cases of COVID-19 were identified and 55 cluster positives were recorded during the study period. 0 (0%) cluster positives were recorded during the pre-Delta variant wave, 3 (5%) cluster positives were recorded during the Delta variant wave, and 52 (95%) cluster positives were recorded during the Omicron variant wave. Additionally, 23 (85%) of all positives during pre-Delta, 12 (50%) of all positives during Delta, 66 (61%) of all positives during Omicron, and 36 (69%) of cluster positives during Omicron did not receive CDC-recommended dosages of the COVID-19 vaccine.

conclusionThe Omicron variant led to an increase in cluster-based transmission, and staying up to date with vaccination guidelines was crucial in limiting transmission. CLINICAL

trial registrationPrior to enrollment, this study was registered at ClinicalTrials.gov on September 25, 2020 (identifier NCT04565509; titled "Supporting the Health and Well-being of Children with Intellectual and Developmental Disability During COVID-19 Pandemic").

Indexed as

Cluster transmissionIntellectual and developmental disabilitiesOmicron variantSARS-CoV-2Vaccinations

Identifiers

PMID37704799
PMCPMC10581949

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.