Evidence map›Paper›PMID 37704796›Full record

SynthesisEuropean journal of clinical pharmacology2023

Isopropyl alcohol inhalation versus 5-HT

James S Kimber, Joshua G Kovoor, John M Glynatsis, Samuel J West, Thi Thien Nhi Mai, Jonathan Henry W Jacobsen, Christopher D Ovenden, Stephen Bacchi, Joseph N Hewitt, Aashray K Gupta and 3 more

Open access · hybridAbstract readReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

James S KimberFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia. james.kimber@adelaide.edu.au.ORCID http://orcid.org/0000-0002-3625-8367
Joshua G KovoorFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.ORCID http://orcid.org/0000-0002-3880-3840
John M GlynatsisFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.
Samuel J WestCentral Adelaide Local Health Network, Adelaide, SA, Australia.
Thi Thien Nhi MaiCentral Adelaide Local Health Network, Adelaide, SA, Australia.
Jonathan Henry W JacobsenResearch, Audit and Academic Surgery, Royal Australasian College of Surgeons, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0001-7735-7532
Christopher D OvendenFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.ORCID http://orcid.org/0000-0001-8075-7852
Stephen BacchiFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.
Joseph N HewittFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.
Aashray K GuptaFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.
Suzanne EdwardsAdelaide Health Technology Assessment, School of Public Health, University of Adelaide, Adelaide, SA, Australia.
Fiona J TavernerFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia.
David I WatsonCollege of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-7683-2693
The University of Adelaide · AUCentral Adelaide Local Health NetworkRoyal Australasian College of Surgeons · AUFlinders Medical Centre · AUFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT

methodsMEDLINE, EMBASE, PubMed, CENTRAL and CINAHL were searched from inception to 17 July 2023 for randomised controlled trials (RCTs) comparing inhaled IPA and a 5-HT

resultsFrom 1242 records, 4 RCTs were included with 382 participants. Participants receiving IPA had a significantly lower mean time to 50% reduction in nausea (MD - 20.06; 95% CI - 26.26, - 13.85). Nausea score reduction at 30 min was significantly greater in the IPA group (MD 21.47; 95% CI 15.47, 27.47). IPA led to significantly reduced requirement for rescue antiemetics (OR 0.60; 95% CI 0.37, 0.95; p = 0.03). IPA led to no significant difference in patient satisfaction when compared with a 5-HT

conclusionIPA may provide rapid, effective relief of nausea when compared with 5-HT

Indexed as

AntiemeticsSerotonin2-PropanolHumansNauseaSerotonin 5-HT3 Receptor Antagonists2-PropanolAntiemeticsSerotoninSerotonin 5-HT3 Receptor Antagonists5-HT3 antagonistAromatherapyIsopropyl alcoholNausea

Identifiers

PMID37704796
PMCPMC10618376
OpenAlexW4386726836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.