ArticleNature2023
Single-cell brain organoid screening identifies developmental defects in autism.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 178 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 1 pooled it
34.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 1 synthesis or guideline pooled it, 224 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Advances in the treatment of autism spectrum disorder: Wharton jelly mesenchymal stem cell transplantation.World journal of methodology · 2025Trial
- Construction and characterization of a cardiac organoid ARVC disease model with its application in gene therapy targetingGenes & diseases · 2027Article
- Real-time sensing-integrated organoid-on-a-chip platforms: Technological progress and emerging biomedical applications.Bioactive materials · 2026Review
- PACS1 syndrome variant alters the proteomic landscape of developing cortical organoids.iScience · 2026Article
- Model Systems infrastructure of the German Center for Mental Health (DZPG): toward an integrated, mechanism-based framework for mental health research.European archives of psychiatry and clinical neuroscience · 2026Review
- Pathological Priming and Developmental Heterochrony as Organizing Concepts in Human iPSC Models of Autism Spectrum Disorder.Molecular neurobiology · 2026Review
- Stem cell derived neural organoid approaches for neurological diseases.Neural regeneration research · 2026Article
- Brain organoids as models of extracellular vesicle-mediated human neural communication.Neural regeneration research · 2026Article
- Disrupted PQBP1-HNRNPU-LINE-1 axis underlies aberrant neurodevelopment in renpenning syndrome.Molecular psychiatry · 2026Article
- Tutorial: interrogating biology using organoid technologies.Nature protocols · 2026Review
- CRISPR-Enabled functional genomics in hPSCs-derived neural models for autism spectrum disorder.Metabolic brain disease · 2026Review
- Elucidating the role of DEAF1 in neurodevelopment and shared molecular pathways in high-risk autism genes using cortical organoids.Science advances · 2026Article
- Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.Stem cell reports · 2026Article
- Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons.bioRxiv : the preprint server for biology · 2026Article
- CRISPR-Cas9 and precision editing technologies linking functional genomics to clinical translation in genetic diseases.Clinical and translational medicine · 2026Review
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.Molecules and cells · 2026Article
- Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.Molecular psychiatry · 2026Article
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
118 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 2 countries.
Chong Li *Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria. chong.li@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0003-2823-7360
Jonas Simon Fleck *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Catarina Martins-CostaInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0003-2018-898X
Thomas R BurkardInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0002-0884-2929
Jan ThemannInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0009-0004-0892-2138
Marlene StuempflenDepartment of Radiodiagnostics, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-9763-9422
Angela Maria PeerInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.
Ábel VertesyInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0001-6075-5702
Jamie B LittleboyInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0002-1847-0794
Christopher EskInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0003-1833-0801
Ulrich EllingInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0002-4514-2809
Gregor KasprianDepartment of Radiodiagnostics, Medical University of Vienna, Vienna, Austria.
Nina S CorsiniInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0001-6731-3544
Barbara TreutleinDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.ORCID http://orcid.org/0000-0002-3299-5597
Juergen A KnoblichInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria. juergen.knoblich@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0002-6751-3404
Institute of Molecular Biotechnology · ATETH Zurich · CHMedical University of Vienna · AT
Funding
Austrian Science Fund FWF DOC 72European Research Council
Abstract
The development of the human brain involves unique processes (not observed in many other species) that can contribute to neurodevelopmental disorders
Indexed as
Autism Spectrum DisorderBrainDevelopmental DisabilitiesOrganoidsSingle-Cell Gene Expression AnalysisAutistic DisorderCell LineageChromatinCRISPR-Associated Protein 9CRISPR-Cas SystemsDNA-Binding ProteinsDNA HelicasesGene EditingHumansLoss of Function MutationMosaicismARID1B protein, humanChromatinCRISPR-Associated Protein 9DNA-Binding ProteinsDNA HelicasesNuclear ProteinsRNA, Guide, CRISPR-Cas SystemsSMARCA2 protein, humanSMARCA4 protein, humanTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.