ArticleNature2023
A vertebral skeletal stem cell lineage driving metastasis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
21.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 75 citations in OpenAlex.
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- Bone-Targeted Nanosystems Induce Multiple Types of Cell Death and Suppress Osteoclasts via Sonodynamic Sensitization Therapy to Treat Bone Metastatic Tumors.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Mechanisms limiting the long-term anabolic effects of teriparatide (PTH 1-34) on bone.JBMR plus · 2026Review
- Expanding the phenotypic spectrum associated with ZIC1 variants: A neurodevelopmental disorder with and without craniosynostosis.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- A tissue engineering approach to regenerate the cranial suture skeletal stem cell niche with a multicompartment biomaterial scaffold.Bone research · 2026Article
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- Type E endothelial cells orchestrate embryonic skeletogenesis via chondrogenic priming of skeletal progenitors.Journal of orthopaedic translation · 2026Article
- Vertebral metastatic disease: A paradigm shift.Neuro-oncology advances · 2026Review
- The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities.Molecular cancer · 2026Review
- Increased angiogenesis-osteogenesis coupling in the endplate at early stages of intervertebral disc degeneration.Scientific reports · 2026Article
- Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026Review
- Fibrous-layer resident Angptl7Cell research · 2026Article
- Engineered bone matrix models for understanding breast cancer skeletal metastasis.Cancer metastasis reviews · 2026Review
- Targeting Osteoclastogenesis: Sabutoclax reduces tumor-associated osteolysis and tumor burden within the bone microenvironment.American journal of cancer research · 2026Article
- PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma.American journal of cancer research · 2026Review
- Bone formation niche dysfunction in osteoporosis: insights from single-cell and spatial transcriptomic studies.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 2 countries.
Jun SunDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-9099-1829
Lingling HuDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-1797-7390
Seoyeon BokDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6063-1224
Alisha R YallowitzDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Michelle CungDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2457-4266
Jason McCormickFlow Cytometry Core Facility, Weill Cornell Medicine, New York, NY, USA.ORCID 0009-0007-0052-4727
Ling J ZhengDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Shawon DebnathDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-2164-1213
Yuzhe NiuDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Adrian Y TanGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Sarfaraz LalaniDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3624-9409
Kyle W MorseDepartment of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.
Daniel ShinnDepartment of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.
Anthony PajakDepartment of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.
Mohammed HammadResearch Division, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0001-7242-5348
Vincentius Jeremy SuhardiResearch Division, Hospital for Special Surgery, New York, NY, USA.
Zan LiDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4873-4471
Na LiState Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University, Xiamen, China.
Lijun WangInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Weiguo ZouInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.ORCID 0000-0003-2516-0302
Vivek MittalDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4764-7413
Mathias P G BostromResearch Division, Hospital for Special Surgery, New York, NY, USA.
Ren XuState Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University, Xiamen, China.ORCID 0000-0001-6578-4553
Sravisht IyerDepartment of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. mag3003@med.cornell.edu.ORCID 0000-0001-9794-8532
Cornell University · USHospital for Special Surgery · USShanghai Jiao Tong University · CNXiamen University · CN
Funding
Weill Cornell Medicine (WCM) SPORE in Prostate CancerP50CA211024 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELEMENTO, OLIVIER · 2017 to 2021
$10.9MHSS Research Institute Rheumatology TrainingT32AR071302 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ALESSANDRA B PERNIS, Jane E Salmon · 2017 to 2026
$2.3MModulation of Bone Formation by SHN3DP5OD021351 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2015 to 2019
$2.1M"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"R01AR075585 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2020 to 2024
$1.8MCombined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7MA multi-stem cell basis for CraniosynostosisK99DE031819 · NIDCR · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEBNATH, SHAWON · 2022 to 2023
$270kNCI NIH HHS P50 CA211024NIAMS NIH HHS R01 AR075585NIAMS NIH HHS T32 AR071302NIAMS NIH HHS T32 AR078751NIDCR NIH HHS K99 DE031819NIH HHS DP5 OD021351
Abstract
Vertebral bone is subject to a distinct set of disease processes from long bones, including a much higher rate of solid tumour metastases
Indexed as
Breast NeoplasmsCell LineageNeoplasm MetastasisSpineStem CellsAntigens, SurfaceBiomarkersCell DifferentiationCell Self RenewalHumansMilk ProteinsOsteoblastsPaired Box Transcription FactorsTranscription FactorsAntigens, SurfaceBiomarkersMFGE8 protein, humanMilk ProteinsPaired Box Transcription FactorsPAX1 transcription factorTranscription FactorsZIC1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.