Evidence map›Paper›PMID 37704728›Full record

ArticleNature2023

A foundation model for generalizable disease detection from retinal images.

Yukun Zhou, Mark A Chia, Siegfried K Wagner, Murat S Ayhan, Dominic J Williamson, Robbert R Struyven, Timing Liu, Moucheng Xu, Mateo G Lozano, Peter Woodward-Court and 8 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 453 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
453citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

453 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. A Facial Foundation Model for Clinical Biomarker Prediction and Real-World Mobile Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Article
  13. Article
  14. Current Trends in AI and Eye Disease Diagnostics.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  19. Detecting Uniformity Artifacts in Ultrasound Transducers: Insights from Clinical Median Images and Deep Learning for Automatic Detection.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  20. Multimodal Nomogram for the Prenatal Risk Assessment of Hypoplastic Left Heart Syndrome Using Self-Supervised Learning.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article

393 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yukun ZhouCentre for Medical Image Computing, University College London, London, UK. yukun.zhou.19@ucl.ac.uk.ORCID 0000-0002-0840-6422
Mark A ChiaNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Siegfried K WagnerNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Murat S AyhanCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0002-3184-2353
Dominic J WilliamsonCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0001-5219-9312
Robbert R StruyvenCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0002-2201-859X
Timing LiuNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK.ORCID 0000-0003-2834-3040
Moucheng XuCentre for Medical Image Computing, University College London, London, UK.
Mateo G LozanoNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK.ORCID 0000-0003-1686-7189
Peter Woodward-CourtCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0002-7913-1403
Yuka KiharaDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
UK Biobank Eye & Vision Consortium
Andre AltmannCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0002-9265-2393
Aaron Y LeeDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
Eric J TopolDepartment of Molecular Medicine, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-1478-4729
Alastair K DennistonAcademic Unit of Ophthalmology, University of Birmingham, Birmingham, UK.ORCID 0000-0001-7849-0087
Daniel C AlexanderCentre for Medical Image Computing, University College London, London, UK.ORCID 0000-0003-2439-350X
Pearse A KeaneNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, UK. p.keane@ucl.ac.uk.

Funding

Medical Research Council MC_PC_19005Medical Research Council MC_UU_00007/10Medical Research Council MR/K003364/1Medical Research Council MR/T019050/1
6 · The paper itself

Abstract

Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis of eye diseases and systemic disorders

Indexed as

Artificial IntelligenceEye DiseasesRetinaHeart FailureHumansMyocardial InfarctionSupervised Machine Learning

Identifiers

PMID37704728
PMCPMC10550819

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.