Evidence map›Paper›PMID 37704721›Full record

ArticleNature2023

Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.

Danyang Zhang, Josip Ivica, James M Krieger, Hinze Ho, Keitaro Yamashita, Imogen Stockwell, Rozbeh Baradaran, Ondrej Cais, Ingo H Greger

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  10. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
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  15. Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Danyang Zhang *Neurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Josip Ivica *Neurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
James M Krieger *Biocomputing Unit, National Center of Biotechnology, CSIC, Madrid, Spain.
Hinze HoNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Keitaro YamashitaStructural Studies Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5442-7582
Imogen StockwellNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Rozbeh BaradaranNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-6096-9169
Ondrej CaisNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Ingo H GregerNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK. ig@mrc-lmb.cam.ac.uk.ORCID 0000-0002-7291-2581
MRC Laboratory of Molecular Biology · GBCentro Nacional de Biotecnología · ES

Funding

Medical Research Council MC_U105174197Medical Research Council MC_UP_A025_1012Wellcome Trust
6 · The paper itself

Abstract

AMPA glutamate receptors (AMPARs), the primary mediators of excitatory neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca

Indexed as

Glutamic AcidSynaptic Transmissionalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCryoelectron MicroscopySynapsesalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidGlutamic Acid

Identifiers

PMID37704721
PMCPMC10533411
OpenAlexW4386700157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.