ArticleScientific reports2023
Prefrontal hypoactivation induced via social stress is more strongly associated with state rumination than depressive symptomatology.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Investigating the neural and behavioral correlates of the stress-rumination link in healthy humans by modulating the left Dorsolateral Prefrontal Cortex using Theta Burst Stimulation.Cognitive, affective & behavioral neuroscience · 2025Trial
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Rumination Out Loud? Linguistic, Neural, and Psychophysiological Correlates of the Think-Aloud Paradigm.Depression and anxiety · 2026Article
- Exploring the effects of short-term forest bathing on anxious medical undergraduates' stressful emotions using near-infrared functional brain imaging and facial expression technology.Frontiers in psychology · 2026Article
- Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination.Scientific reports · 2025Article
- Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation.Neurobiology of stress · 2025Article
- Neural correlates of stress-reactive rumination in depression - The role of childhood trauma and social anxiety.Neurobiology of stress · 2024Article
- Self-objectification and eating disorders: the psychopathological and neural processes from psychological distortion to psychosomatic illness.Psychoradiology · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have consistently shown a pattern of prefrontal hypoactivation in depressed patients (DP); however, it remains unclear whether this neural correlate is a consequence or concomitant feature of depression and/or whether ruminative thinking might be underlying. Using a sample comprising 65 healthy controls (HC) and 77 DP, we investigated the behavioral and neural correlates in response to stress and their association with depressive symptomatology, trait and state rumination. Fitting repeated-measurement MANOVAs including 21 fNIRS-channels covering the bilateral Inferior Frontal Gyrus (IFG), Dorsolateral Prefrontal Cortex (DLPFC) and Somatosensory Association Cortex (SAC), we investigated the predictive value of diagnostic group (HC vs. DP) and state rumination. In DP, we observed significantly lower increases in cortical oxygenation under stress in channels of the right IFG and bilateral DLPFC. Participants reporting lower state rumination and no increases in state rumination under stress showed higher increases in cortical oxygenation compared to the other groups and in more channels compared to the analysis on diagnostic group. Re-running our fNIRS-analysis while correcting for performance resulted in time-dependent changes dependent on group (DP vs. HC) no longer yielding significance, however for the differentiation of state rumination groups.
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