ArticleNature communications2023
Chiral recognition of neutral guests by chiral naphthotubes with a bis-thiourea endo-functionalized cavity.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Chalcogen-bonding-mediated chiral recognition and enantioenrichment of organoselenocyanates.Chemical science · 2026Article
- Dynamic Covalent Platform for Chiroptically Tunable Figure-Eight Macrocycles from Preorganized Alkaloidal Scaffolds.JACS Au · 2026Article
- Visualization of enantiorecognition by excited-state conformation modulation.Nature communications · 2025Article
- Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube.RSC advances · 2025Article
- Stimulating Chiral Selective Expression of Room Temperature Phosphorescence for Chirality Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Investigating the diastereoselective synthesis of a macrocycle under Curtin-Hammett control.Chemical science · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Developing chiral receptors with an endo-functionalized cavity for chiral recognition is of great significance in the field of molecular recognition. This study presents two pairs of chiral naphthotubes containing a bis-thiourea endo-functionalized cavity. Each chiral naphthotube has two homochiral centers which were fixed adjacent to the thiourea groups, causing the skeleton and thiourea groups to twist enantiomerically through chiral transfer. These chiral naphthotubes are highly effective at enantiomerically recognizing various neutral chiral molecules with an enantioselectivity up to 17.0. Furthermore, the mechanism of the chiral recognition has been revealed to be originated from differences in multiple non-covalent interactions. Various factors, such as the shape of cavities, substituents of guests, flexibility of host and binding modes are demonstrated to contribute to creating differences in the non-covalent interactions. Additionally, the driving force behind enantioselectivity is mainly attributed to enthalpic differences, and enthalpy -entropy compensation has also been observed to influence enantioselectivity.
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Registered trials
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