Evidence map›Paper›PMID 37704629›Full record

ArticleNature communications2023

Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo.

Jeffrey Y K Wong, Arunika I Ekanayake, Serhii Kharchenko, Steven E Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X Fernandez, Edgar R Alvizo-Paez and 12 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Universal Baseline forbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Jeffrey Y K Wong *Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.ORCID http://orcid.org/0000-0003-2720-7872
Arunika I Ekanayake *Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
Serhii KharchenkoDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
Steven E KirbergerDepartment of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Ryan QiuDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.ORCID http://orcid.org/0000-0002-7586-8475
Payam KelichDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX, 79968, USA.ORCID http://orcid.org/0000-0002-6441-6326
Susmita SarkarDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
Jiaqian LiDepartment of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Kleinberg X FernandezDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
Edgar R Alvizo-PaezDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
Jiayuan MiaoDepartment of Chemistry, Tufts University, Medford, MA, 02155, USA.ORCID http://orcid.org/0000-0003-1112-1927
Shiva Kalhor-MonfaredDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
J Dwyer JohnFerring Research Institute, San Diego, CA, 92121, USA.
Hongsuk KangQuantum Intelligence Corp., 31F, One IFC, 10 Gukjegeumyung-ro, Yeongdeungpo-gu-Seoul, Republic of Korea.
Hwanho ChoiQuantum Intelligence Corp., 31F, One IFC, 10 Gukjegeumyung-ro, Yeongdeungpo-gu-Seoul, Republic of Korea.
John M NussFerring Research Institute, San Diego, CA, 92121, USA.
John C VederasDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.ORCID http://orcid.org/0000-0002-2996-0326
Yu-Shan LinDepartment of Chemistry, Tufts University, Medford, MA, 02155, USA.ORCID http://orcid.org/0000-0001-6460-2877
Matthew S MacauleyDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.ORCID http://orcid.org/0000-0003-4579-1048
Lela VukovicDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX, 79968, USA.ORCID http://orcid.org/0000-0002-9053-5708
William C K PomerantzDepartment of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-0163-4078
Ratmir DerdaDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada. ratmir@ualberta.ca.ORCID http://orcid.org/0000-0003-1365-6570
University of Alberta · CAUniversity of Minnesota · USThe University of Texas at El Paso · USTufts University · US

Funding

Understanding and Designing Cyclic PeptidesR01GM124160 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI Yu-Shan Lin · 2017 to 2026
$3.2M
Chemical Probe Development for Epigenetic Complexes Enabled by Protein-Observed 19F NMRR35GM140837 · NIGMS · UNIVERSITY OF MINNESOTA · PI William Charles Krause Pomerantz · 2021 to 2026
$2.5M
NIGMS NIH HHS R01 GM124160NIGMS NIH HHS R35 GM140837
6 · The paper itself

Abstract

Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine S

Indexed as

AlbuminsSerum Albumin, HumanAngiotensin IIAnimalsApelinCysteineHumansMiceSulfidesAlbuminsAngiotensin IIApelinCysteineSerum Albumin, HumanSulfides

Identifiers

PMID37704629
PMCPMC10499988
OpenAlexW4386709864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.