Evidence map›Paper›PMID 37704464›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2023

Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways.

Do-Yeon Cho, Shaoyan Zhang, Daniel Skinner, Connor G Koch, Metta J Smith, Dong-Jin Lim, Jessica W Grayson, Guillermo J Tearney, Steven M Rowe, Bradford A Woodworth

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Do-Yeon ChoDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Otolaryngology, Department of Surgery, Veteran Affairs Medical Center, Birmingham, AL, USA.
Shaoyan ZhangDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Daniel SkinnerDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Connor G KochDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Metta J SmithDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Dong-Jin LimDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessica W GraysonDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Steven M RoweGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Departments of Medicine, Pediatrics, Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Bradford A WoodworthDepartment of Otolaryngology - Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: bwoodwo@uab.edu.
University of Alabama at Birmingham · USMassachusetts General Hospital · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI David M. Bedwell · 2007 to 2026
$23.0M
Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisR01HL133006 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2016 to 2020
$1.7M
Dysbiosis of the Sinus Microbiota in Chronic RhinosinusitisK08AI146220 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2019 to 2021
$467k
Impact of mucin fermenting microbes on the virulence of Pseudomonas aeruginosa in chronic rhinosinusitisR21AI168894 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2022 to 2023
$408k
A Ginsenoside TMEM16A Potentiator for Cystic FibrosisR21AT012234 · NCCIH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2023 to 2024
$405k
NCCIH NIH HHS R21 AT012234NHLBI NIH HHS R01 HL133006NIAID NIH HHS K08 AI146220NIAID NIH HHS R21 AI168894NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

backgroundWe previously discovered that Korean red ginseng aqueous extract (RGAE) potentiates the TMEM16A channel, improved mucociliary transport (MCT) parameters in CF nasal epithelia in vitro, and thus could serve as a therapeutic strategy to rescue the MCT defect in cystic fibrosis (CF) airways. The hypothesis of this study is that RGAE can improve epithelial Cl

methodsSeventeen 4-month old CFTR

resultsRGAE-treated CF rats had greater mean NPD polarization with UTP (control = -5.48 +/- 2.87 mV, RGAE = -9.49 +/- 2.99 mV, p < 0.05), indicating, at least in part, potentiation of UTP-mediated Cl

conclusionRGAE improves TMEM16A-mediated transepithelial Cl

Indexed as

Cystic FibrosisAnimalsCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsHumansIon TransportMucociliary ClearanceRatsUridine TriphosphateCystic Fibrosis Transmembrane Conductance RegulatorUridine TriphosphateCalcium-activated chloride channelCFTRCystic fibrosisCystic fibrosis ratFunctional microanatomyGinsenosideMicro-optical coherence tomographyMucociliary clearanceMucociliary transportNasal potential differenceRed ginsengTMEM16ATMEM16A potentiator

Identifiers

PMID37704464
PMCPMC10843063
OpenAlexW4386621162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.