Evidence map›Paper›PMID 37704356›Full record

ReviewPediatric clinics of North America2023

Current Practices in Pharmacogenomics.

Laura B Ramsey, Cynthia A Prows, Sonya Tang Girdwood, Sara Van Driest

Abstract readReview
In one paragraph

Review in Pediatric clinics of North America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura B RamseyDivision of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229, USA; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 9016, Cincinnati, OH 45529, USA. Electronic address: laura.ramsey@cchmc.org.
Cynthia A ProwsDivision of Human Genetics, Department of Pediatrics and Center for Professional Excellence, Patient Services, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, MLC 6018, Cincinnati, OH 45229, USA.
Sonya Tang GirdwoodDepartment of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 9016, Cincinnati, OH 45529, USA; Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 9016, Cincinnati, OH 45529, USA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 9016, Cincinnati, OH 45529, USA.
Sara Van DriestDepartment of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, 8232 DOT, Nashville, TN 37205, USA.

Funding

Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)P50HD106446 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PRINCE Joseph KANNANKERIL, Digna R Velez Edwards · 2021 to 2026
$9.7M
Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial NetworkU01HG010232 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAVANAUGH, KERRI, PETERSON, JOSEPH F. · 2018 to 2024
$8.2M
Polygenic Risk Scores for Healthier African American FamiliesU01HG011172 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, LISA J MARTIN · 2020 to 2026
$7.2M
Engaging adolescents in decisions about return of genomic research resultsR01HG010166 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI MCGOWAN, MICHELLE L, MYERS, MELANIE F · 2019 to 2023
$3.6M
T32 Cincinnati Pediatric Clinical Pharmacology Training ProgramT32HD069054 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI TRACY A GLAUSER, Sonya C Tang Girdwood · 2011 to 2026
$3.0M
Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety Disorders Using Pharmacogenetically-guided DosingR01HD099775 · NICHD · UNIVERSITY OF CINCINNATI · PI RAMSEY, LAURA B, STRAWN, JEFFREY ROBERT · 2020 to 2024
$2.9M
Identifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIAR01HD089928 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BECKER, MARA LEIGH, THOMPSON, SUSAN D · 2017 to 2021
$2.8M
Antibiotic Model-Informed Precision Dosing in Critical IllnessR35GM146701 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Sonya C Tang Girdwood · 2022 to 2026
$2.0M
Genomic Approaches for Predicting Drug ResponseR01GM132204 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KANNANKERIL, PRINCE JOSEPH · 2019 to 2023
$1.8M
NHGRI NIH HHS R01 HG010166NHGRI NIH HHS U01 HG010232NHGRI NIH HHS U01 HG011172NICHD NIH HHS P50 HD106446NICHD NIH HHS R01 HD089928NICHD NIH HHS R01 HD099775NICHD NIH HHS T32 HD069054NIGMS NIH HHS R01 GM132204NIGMS NIH HHS R35 GM146701
6 · The paper itself

Abstract

Pharmacogenomics, where genomic information is used to tailor medication management, is a strategy to maximize drug efficacy and minimize toxicity. Although pediatric evidence is less robust than for adults, medications influenced by pharmacogenomics are prescribed to children and adolescents. Evidence-based guidelines and drug label annotations are available from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Pharmacogenomics Knowledgebase (PharmGKB). Some pediatric health care facilities use pharmacogenomics to provide dosing recommendations to pediatricians. Herein, we use a case-based approach to illustrate the use of pharmacogenomic data in pediatric clinical care and provide resources for finding and using pharmacogenomic guidelines.

Indexed as

PediatriciansPharmacogeneticsAdolescentAdultChildHumansGenomicsGuidelinesPediatricsPharmacogenetics

Identifiers

PMID37704356
PMCPMC10865383

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.