Evidence map›Paper›PMID 37704099›Full record

ArticleOsteoarthritis and cartilage2023

Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: Findings from a cross-sectional study in UK Biobank.

S V Heppenstall, R Ebsim, F R Saunders, C Lindner, J S Gregory, R M Aspden, N C Harvey, T Cootes, J H Tobias, M Frysz and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Are birth characteristics related to bone quality measures in young adults? The HUNT study, Norway.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  4. DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  5. Review
  6. Article
  7. Femoral neck width genetic risk score is a novel independent risk factor for hip fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

S V HeppenstallMusculoskeletal Research Unit, University of Bristol, UK.
R EbsimDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
F R SaundersCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
C LindnerDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
J S GregoryCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
R M AspdenCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
N C HarveyMedical Research Council Lifecourse Epidemiology Centre, University of Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK.
T CootesDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
J H TobiasMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
M FryszMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
B G FaberMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK. Electronic address: ben.faber@bristol.ac.uk.
University of Aberdeen · GBUniversity of Manchester · GBNIHR Oxford Musculoskeletal Biomedical Research Centre · GBUniversity of Bristol · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Medical Research Council MC_PC_21003Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00032/1Medical Research Council MR/S021280/1Wellcome Trust 209233Wellcome Trust 209233/Z/17/ZWellcome Trust 223267Wellcome Trust 223267/Z/21/Z
6 · The paper itself

Abstract

objectiveTo examine the extent to which geometric parameters derived from dual-energy x-ray absorptiometry (DXA) scans in the UK Biobank study are related to hip osteoarthritis (HOA) independently of sex, age and body size.

designFemoral neck width (FNW), diameter of the femoral head (DFH) and hip axis length (HAL) were derived automatically from left hip DXA scans in UK Biobank using outline points placed around the hip by a machine-learning program. Correlations were calculated between geometric parameters, age, height, and weight. Logistic regression was used to examine the relationship of geometric parameters with radiographic HOA, hospital diagnosed HOA (HESOA), and Cox proportional hazards model to evaluate the relationship with total hip replacement (THR). Analyses were adjusted for sex, age, height, weight, and geometric parameters.

resultsThe study consisted of 40,312 participants. In age and sex-adjusted analyses, FNW, HAL and DFH were related to increased risk of radiographic HOA. In a model adjusted for age, sex, height, weight and other geometric parameters, both FNW and HAL retained independent relationships with radiographic HOA [FNW: odds ratios 2.38 (2.18-2.59), HAL: 1.25 (1.15-1.36)], while DFH was now protective [0.55 (0.50-0.61)]. Only FNW was independently related to HESOA [2.20 (1.80-2.68)] and THR [hazard ratios 2.51 (1.89-3.32)].

conclusionGreater FNW and HAL were independently related to an increased risk of radiographic HOA, whereas greater DFH appeared to be protective. Greater FNW was independently associated with HESOA and THR. These results suggest that DXA-derived geometric parameters, particularly FNW, could help determine HOA and THR risk.

Indexed as

Bone DensityOsteoarthritis, HipAbsorptiometry, PhotonBiological Specimen BanksCross-Sectional StudiesHumansRisk FactorsUnited KingdomDXAEpidemiologyHip geometryHip osteoarthritisHip shape

Identifiers

PMID37704099
PMCPMC7615936
OpenAlexW4386609795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.