ArticleBrain stimulation
TMS over the pre-SMA enhances semantic cognition via remote network effects on task-based activity and connectivity.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Stimulation success!? Improved response inhibition performance after prefrontal single-site and condition-and-perturb transcranial magnetic stimulation.Cognitive, affective & behavioral neuroscience · 2026Article
- Mapping shared and specific cortical after-effects of repetitive TMS on brain function.BMC medicine · 2026Article
- Target-Specificity and repeatability in neuro-cardiac-guided TMS for heart-brain coupling.Translational psychiatry · 2026Article
- Resilience through regulation: Individual differences in inhibitory control shape neural and psychological responses to ostracism.Cognitive, affective & behavioral neuroscience · 2026Article
- Intranasal (R)-ketamine modulates depression symptom and neurotransmitters-associated human brain connectivity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Functional differentiation and interactions among inferior, medial frontal and posterior temporal cortex in semantic control.Communications biology · 2025Article
- Causal contributions of left inferior and medial frontal cortex to semantic and executive control.Communications biology · 2025Article
- Functional Disconnections of the Pre-Supplementary Motor Area in Patients With Post-Stroke Aphasia and Their Associations With Neurotransmitters.CNS neuroscience & therapeutics · 2025Article
- Temporo-frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross-cohort comparison.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Repetitive transcranial magnetic stimulation to alleviate fatigue in multiple sclerosis-study protocol for a randomized sham-controlled double-blinded clinical trial.Frontiers in neurologyArticle
- Effects and mechanisms of theta burst stimulation targeting individualized pre-supplementary motor area for post-stroke aphasia: study protocol for a randomized controlled trial.Frontiers in neurologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe continuous decline of executive abilities with age is mirrored by increased neural activity of domain-general networks during task processing. So far, it remains unclear how much domain-general networks contribute to domain-specific processes such as language when cognitive demands increase. The current neuroimaging study explored the potential of intermittent theta-burst stimulation (iTBS) over a domain-general hub to enhance executive and semantic processing in healthy middle-aged to older adults.
methodsWe implemented a cross-over within-subject study design with three task-based neuroimaging sessions per participant. Using an individualized stimulation approach, each participant received once effective and once sham iTBS over the pre-supplementary motor area (pre-SMA), a region of domain-general control. Subsequently, task-specific stimulation effects were assessed in functional MRI using a semantic and a non-verbal executive task with varying cognitive demand.
resultsEffective stimulation increased activity only during semantic processing in visual and dorsal attention networks. Further, iTBS induced increased seed-based connectivity in task-specific networks for semantic and executive conditions with high cognitive load but overall reduced whole-brain coupling between domain-general networks. Notably, stimulation-induced changes in activity and connectivity related differently to behavior: While stronger activity of the parietal dorsal attention network was linked to poorer semantic performance, its enhanced coupling with the pre-SMA was associated with more efficient semantic processing.
conclusionsiTBS modulates networks in a task-dependent manner and generates effects at regions remote to the stimulation site. These neural changes are linked to more efficient semantic processing, which underlines the general potential of network stimulation approaches in cognitive aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.