ArticleJournal of neurophysiology2023
Laminar pattern of adolescent development changes in working memory neuronal activity.
Article in Journal of neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 6 citations in OpenAlex.
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Asynchronous firing and off states in working memory maintenance.Cell reports · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Asynchronous firing and off-states in working memory maintenance.bioRxiv : the preprint server for biology · 2025Article
- Heterochronous laminar maturation in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Local organization of spatial and shape information in the primate prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
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4 authors at 1 institution in 1 country.
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Abstract
Adolescent development is characterized by an improvement in cognitive abilities, such as working memory. Neurophysiological recordings in a nonhuman primate model of adolescence have revealed changes in neural activity that mirror improvement in behavior, including higher firing rate during the delay intervals of working memory tasks. The laminar distribution of these changes is unknown. By some accounts, persistent activity is more pronounced in superficial layers, so we sought to determine whether changes are most pronounced there. We therefore analyzed neurophysiological recordings from the young and adult stage of male monkeys, at different cortical depths. Superficial layers exhibited an increased baseline firing rate in the adult stage. Unexpectedly, we also detected substantial increases in delay period activity in the middle layers after adolescence, which was confirmed even after excluding penetrations near sulci. Finally, improved discriminability around the saccade period was most evident in the deeper layers. These results reveal the laminar pattern of neural activity maturation that is associated with cognitive improvement.
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